Vialox (Pentapeptide-3V) (200mg) Research Peptide: A nAChR Antagonist for Neuromuscular & Dermal Studies

If your research investigates neuromuscular signalling, nicotinic acetylcholine receptor (nAChR) pharmacology, or the molecular mechanisms underlying muscle contraction and dermal applications, Vialox (Pentapeptide-3V) (200mg) research peptide — also known as Pentapeptide-3V — offers a precisely defined synthetic tool. Vialox is a pentapeptide with the amino acid sequence Gly‑Pro‑Arg‑Pro‑Ala (GPRPA). It is a synthetic analogue of waglerin‑1, a 22‑amino‑acid peptide isolated from the venom of the temple viper (Tropidolaemus wagleri), which acts as a competitive antagonist at muscle nicotinic acetylcholine receptors (nAChRs). This makes Vialox (Pentapeptide-3V) (200mg) research peptide a valuable tool for laboratories investigating neuromuscular transmission, receptor pharmacology, and the molecular basis of muscle relaxation.

At Chinese Grey Peptides, we supply high‑purity Vialox (Pentapeptide-3V) (200mg) research peptide to research institutions and wholesale buyers across the United Kingdom, France, Germany, Spain, Sweden, Italy, and the USA. Every batch is lyophilised, HPLC‑verified to ≥98% purity, and accompanied by a Certificate of Analysis (COA), ensuring your investigations into neuromuscular signalling and receptor pharmacology begin with uncompromising quality.

What Is Vialox (Pentapeptide-3V) and How Does It Work?

To fully appreciate the research potential of Vialox (Pentapeptide-3V) (200mg) research peptide, it is essential to understand its biochemical structure and the mechanism by which it exerts its effects.

The Pentapeptide-3V Structure

Vialox is a synthetic pentapeptide consisting of five amino acids with the sequence Gly‑Pro‑Arg‑Pro‑Ala (GPRPA). Its molecular formula is C₂₁H₃₇N₉O₅, and its molecular weight is approximately 495.58 g/mol. It has a CAS number of 135679‑88‑8.

The peptide is a synthetic analogue of waglerin‑1, a 22‑amino‑acid peptide originally isolated from the venom of the temple viper (Tropidolaemus wagleri). Waglerin‑1 is known to act as a competitive antagonist at muscle nicotinic acetylcholine receptors (nAChRs)【1†L10-L12】.

Mechanism of Action: Nicotinic Acetylcholine Receptor Antagonism

The biological activity of Vialox (Pentapeptide-3V) (200mg) research peptide is rooted in its ability to act as a competitive antagonist at the muscle nicotinic acetylcholine receptor (nAChR)【1†L20-L21】:

• Receptor Binding: Vialox binds to the nicotinic acetylcholine receptor at the neuromuscular junction, specifically targeting the α1 or ε subunit interface.

• Competitive Inhibition: By occupying the receptor site, it blocks acetylcholine from binding, thereby preventing the receptor from opening its ion channel.

• Reduction of Neuromuscular Signalling: This antagonism reduces neuromuscular excitatory signalling, leading to a relaxation of muscle contractions【1†L21-L22】.

• Reversible Action: The effect of Vialox is reversible, distinguishing it from botulinum toxin, which irreversibly cleaves SNARE proteins【1†L22】.

Research Potency and Selectivity

In vitro studies have demonstrated that Vialox can reduce muscle contraction by up to 82% within 1 minute in certain experimental models【1†L23】. The peptide shows a high selectivity for the neuromuscular junction, making it a useful tool for studying receptor function【2†L14-L15】. Its mechanism is similar to that of other snake venom‑derived peptides like Syn‑AKE, but Vialox is a shorter peptide【2†L16-L17】.

Key Research Applications for Vialox (Pentapeptide-3V) (200mg)

Vialox (Pentapeptide-3V) (200mg) research peptide is a versatile tool with applications spanning several domains of biomedical research.

1. Neuromuscular Signalling & nAChR Pharmacology

As a competitive antagonist at muscle nAChRs, Vialox is a valuable tool for studying receptor function and neuromuscular transmission【1†L20-L22】. Research applications include:

• Receptor Binding Studies: Characterising the binding affinity and kinetics of nAChR ligands【2†L12-L13】.

• Signal Transduction: Investigating the downstream signalling pathways activated by nAChR engagement.

• Comparative Studies: Comparing Vialox with other nAChR antagonists such as Syn‑AKE and waglerin‑1【2†L16-L17】.

• Ion Channel Dynamics: Studying how receptor antagonism affects ion flux and muscle contraction.

2. Dermal & Topical Research

Vialox is frequently studied in the context of topical formulations for its ability to reduce muscle contractions that drive expression lines【1†L30-L31】. Research applications include:

• Anti‑Wrinkle Studies: Investigating the peptide’s ability to reduce expression lines and wrinkles【1†L31】.

• Formulation Development: Studying the stability and delivery of Vialox in topical vehicles【1†L30】.

• Comparative Efficacy: Comparing Vialox with other neuropeptides such as Argireline and Syn‑AKE【2†L16-L17】.

• Skin Penetration: Investigating the skin permeability of Vialox and its formulation requirements【1†L30】.

3. Protein‑Protein Interaction & Molecular Recognition

Beyond its specific role in nAChR pharmacology, Vialox serves as a model system for studying protein‑peptide interactions【2†L12-L13】. Research applications include:

• Structure‑Activity Relationship (SAR) Studies: Investigating how modifications to the Vialox sequence affect receptor binding and activity.

• Molecular Recognition: Exploring the structural requirements for high‑affinity binding to nAChRs.

• Computational Modelling: Developing and validating models of peptide‑receptor interactions.

4. Muscle Physiology & Contractility Research

Vialox’s ability to reduce muscle contraction makes it a valuable tool for studying muscle physiology【1†L20-L22】. Research applications include:

• Muscle Contractility Studies: Investigating the mechanisms of muscle contraction and relaxation.

• Neuromuscular Junction Models: Studying the role of nAChRs in neuromuscular transmission.

• Ischaemia Models: Exploring the potential of Vialox to protect against ischaemia‑induced muscle damage【1†L25】.

Chemical & Physical Specifications for Vialox (Pentapeptide-3V) (200mg)

Accurate characterisation of Vialox (Pentapeptide-3V) (200mg) research peptide is essential for reproducible experimental design.

Note: The 200 mg mass refers to the weight of the peptide in its lyophilised form. Vialox is typically supplied as a TFA or acetate salt, which enhances aqueous solubility. The peptide is a synthetic analogue of the snake venom peptide waglerin‑1【1†L10-L12】.

Reconstitution & Handling Protocol for Vialox (Pentapeptide-3V) (200mg)

Proper reconstitution of Vialox (Pentapeptide-3V) (200mg) research peptide is critical for maintaining its structural integrity and biological activity.

Step 1 – Preparation

• Bring the sealed Vialox vial and your chosen diluent (sterile bacteriostatic water or sterile PBS, pH 5‑7) to room temperature. Condensation can degrade the lyophilised powder.

• Clean your work surface with 70% ethanol and lay out sterile syringes, alcohol wipes and a clean work mat.

Step 2 – Vial Sanitisation

• Wipe the rubber stopper of the Vialox vial with a fresh 70% ethanol wipe. Allow the alcohol to evaporate completely before piercing.

Step 3 – Reconstitution

• Draw your desired volume of diluent into a sterile syringe. A common starting concentration for research applications is 200 mg per 20 mL of diluent, yielding a 10 mg/mL stock solution.

• Insert the needle and slowly inject the diluent against the inner glass wall. Do not spray directly onto the lyophilised powder.

• Gently swirl the vial until the solution is clear and fully dissolved. Do not shake vigorously, as shaking can cause denaturation.

Step 4 – Aliquoting & Storage

• Immediately after dissolution, aliquot the reconstituted Vialox into single‑use sterile vials.

• Store aliquots at –20°C. Avoid repeated freeze‑thaw cycles, as peptides are susceptible to degradation.

• Once thawed, store at 2‑8°C and use within a short period.

Concentration Reference Table for Vialox (Pentapeptide-3V) (200mg)

Adjust diluent volume based on your experimental requirements. For cell culture applications, typical working concentrations may range from 0.1‑10 µM.

Storage & Stability Guidelines for Vialox (Pentapeptide-3V) (200mg)

Why Choose Chinese Grey Peptides for Vialox (Pentapeptide-3V) (200mg)?

As an authentic licensed peptide supplier based in the USA, we supply Vialox (Pentapeptide-3V) (200mg) research peptide and a wide range of research‑grade compounds under rigorous quality assurance protocols, fully aligned with Google’s E‑E‑A‑T standards (Experience, Expertise, Authoritativeness, Trustworthiness).

• Verified Purity: Independent HPLC analysis with purity guaranteed ≥98% for every batch.

• GMP‑Compliant Manufacturing: All peptides are synthesised under strict quality control conditions.

• Full Traceability: Batch‑specific Certificates of Analysis (COA) are available for every order.

• Wholesale Supply: We serve research institutions, laboratories, and wholesale buyers across the UK, EU, and USA with flexible volume pricing and reliable logistics.

• USA‑Based Regulatory Compliance: All products are supplied strictly as research‑grade chemicals for laboratory use only (RUO).

Researchers across the United States—including those at leading institutions—trust us for fast domestic delivery, transparent documentation and professional technical support.

FAQ: Vialox (Pentapeptide-3V) (200mg) Research Peptide

 What is Vialox (Pentapeptide-3V) (200mg) research peptide?
Vialox (Pentapeptide-3V) is a synthetic pentapeptide with the sequence Gly‑Pro‑Arg‑Pro‑Ala (GPRPA). It is a synthetic analogue of waglerin‑1, a peptide from the venom of the temple viper, and acts as a competitive antagonist at muscle nicotinic acetylcholine receptors (nAChRs)【1†L10-L12】.

 What is the sequence and molecular weight of Vialox?
The sequence is Gly‑Pro‑Arg‑Pro‑Ala (GPRPA). Its molecular formula is C₂₁H₃₇N₉O₅, and its molecular weight is approximately 495.58 g/mol.

What are the primary research applications for Vialox?
Vialox is used in neuromuscular signalling and nAChR pharmacology studies (receptor binding, signal transduction), dermal and topical research (anti‑wrinkle studies, formulation development), protein‑protein interaction and molecular recognition studies, and muscle physiology and contractility research.

What is the mechanism of action of Vialox?
Vialox acts as a competitive antagonist at the muscle nicotinic acetylcholine receptor (nAChR). It binds to the receptor at the neuromuscular junction, blocking acetylcholine from binding and reducing neuromuscular excitatory signalling【1†L20-L22】.

 How does Vialox differ from other neuropeptides like Syn‑AKE?
Both Vialox and Syn‑AKE are inspired by snake venom peptides and act as nAChR antagonists. Vialox is a shorter peptide, while Syn‑AKE is a dipeptide derivative【2†L16-L17】.

 What purity does your Vialox (Pentapeptide-3V) (200mg) meet?
Our Vialox is tested to ≥98% purity by HPLC. A Certificate of Analysis (COA) is supplied with every order.

 How should I reconstitute Vialox (Pentapeptide-3V) (200mg)?
Reconstitute with sterile bacteriostatic water or sterile PBS (pH 5‑7). Allow the vial to reach room temperature, then slowly inject the diluent against the inner glass wall and swirl gently. Do not shake. A typical starting concentration is 10 mg/mL【3†L18】.

 How should I store reconstituted Vialox?
Reconstituted Vialox should be stored at 2‑8°C for short‑term use. For longer storage, aliquot immediately into single‑use vials and store at –20°C for up to 3 months. Avoid repeated freeze‑thaw cycles.

Is Vialox research peptide legal to purchase in the USA?
Yes. Vialox is a laboratory reagent sold for research use only (RUO). It is fully legal to purchase, possess, and use in the United States for legitimate in‑vitro or in‑vivo scientific research, provided it is not marketed with therapeutic claims.

Does Chinese Grey Peptides ship internationally?
Yes. We ship across the UK, Europe (France, Germany, Spain, Sweden, Italy), and the USA from our US warehouse. Wholesale pricing is available for bulk orders.

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From its design as a synthetic analogue of the snake venom peptide waglerin‑1 to its well‑characterised role as a reversible antagonist of muscle nicotinic acetylcholine receptors, Vialox (Pentapeptide-3V) (200mg) research peptide provides a precisely defined and increasingly valuable platform for advanced neuromuscular and dermal research. Its ability to modulate neuromuscular signalling through competitive receptor antagonism—supported by peer‑reviewed research and in vitro studies—makes it a valuable addition to any laboratory investigating nAChR pharmacology, neuromuscular signalling, or dermal research. By choosing high‑purity, lab‑verified Vialox (Pentapeptide-3V) (200mg) research peptide from Chinese Grey Peptides, you ensure that your research is built on a foundation of quality, reproducibility, and scientific integrity.

Ready to advance your research with Vialox (Pentapeptide-3V) (200mg)? Browse our product catalogue, request a wholesale quote, or contact our support team today to discuss your laboratory’s specific needs. Place your order now and receive GMP‑grade Vialox delivered directly to your facility in the USA, UK, or Europe.