Kisspeptin-10 (10mg) Research Peptide: A Decapeptide Agonist for GPR54 & Neuroendocrine Studies

If your research investigates the hypothalamic-pituitary-gonadal (HPG) axis, reproductive endocrinology, or the molecular mechanisms of neuroendocrine signalling, Kisspeptin-10 (10mg) research peptide offers a precisely defined and extensively validated synthetic tool. Kisspeptin-10 (KP-10, Metastin 45-54) is the C‑terminal decapeptide amide of the kisspeptin precursor protein, which is the endogenous ligand for the G protein‑coupled receptor GPR54 (also known as KISS1R).

As the minimal bioactive sequence that retains full functional activity, Kisspeptin-10 exhibits higher receptor affinity and biopotency than longer forms of the peptide. It binds with high affinity to rat and human KISS1 receptors with Ki values of 1.59 nM and 2.33 nM, respectively. This makes Kisspeptin-10 (10mg) research peptide a valuable tool for laboratories investigating reproductive endocrinology, neuroendocrine signalling, metastasis suppression, and bone metabolism.

At Chinese Grey Peptides, we supply high‑purity Kisspeptin-10 (10mg) research peptide to research institutions and wholesale buyers across the United Kingdom, France, Germany, Spain, Sweden, Italy, and the USA. Every batch is lyophilised, HPLC‑verified to ≥98% purity, and accompanied by a Certificate of Analysis (COA), ensuring your investigations into the HPG axis, receptor pharmacology, and neuroendocrine signalling begin with uncompromising quality.

What Is Kisspeptin-10 and How Does It Work?

To fully appreciate the research potential of Kisspeptin-10 (10mg) research peptide, it is essential to understand its biochemical structure and the precise mechanism by which it exerts its effects.

The Decapeptide Derived from KISS1

Kisspeptin-10 is a synthetic decapeptide corresponding to the C‑terminal amino acids 45-54 of the kisspeptin precursor protein (metastin). Its sequence is Tyr‑Asn‑Trp‑Asn‑Ser‑Phe‑Gly‑Leu‑Arg‑Phe‑NH₂ (YNWNSFGLRF-NH₂). The peptide has a molecular formula of C₆₃H₈₃N₁₇O₁₄, a molecular weight of approximately 1,302.4‑1,302.45 g/mol, and a CAS number of 374675-21-5. The C‑terminal amidation is essential for its biological activity.

Mechanism of Action: GPR54 (KISS1R) Agonism

The biological activity of Kisspeptin-10 (10mg) research peptide is mediated through its potent and selective activation of the Kisspeptin receptor (KISS1, GPR54):

• High‑Affinity Receptor Binding: Kisspeptin-10 binds with high affinity to rat and human KISS1 receptors with Ki values of 1.59 nM and 2.33 nM, respectively. It exhibits approximately 8‑fold higher binding affinity compared to the full‑length metastin peptide. The receptor is primarily coupled to the Gαq/11 subunit.

• HPG Axis Regulation: Activation of GPR54 in the hypothalamus stimulates the release of luteinising hormone‑releasing hormone (LHRH) from hypothalamic explants. This, in turn, drives the secretion of luteinising hormone (LH) and follicle‑stimulating hormone (FSH) from the pituitary, leading to increased gonadal steroidogenesis. Kisspeptin-10 is a potent stimulator of LH and increases LH pulse frequency in men.

• Direct Pituitary Effects: Kisspeptins also exert direct effects on the pituitary, activating gonadotrophs and somatotrophs and stimulating the secretion of LH and growth hormone.

• Metastasis Suppression: The KISS1 gene was originally discovered as a metastasis suppressor gene. Kisspeptin-10 inhibits tumour angiogenesis and metastasis via its receptor GPR54.

• Bone Metabolism: GPR54 activation by Kisspeptin-10 in osteoclasts suppresses osteoclast activity and prevents bone loss.

Key Research Applications for Kisspeptin-10 (10mg)

Kisspeptin-10 (10mg) research peptide is a versatile tool with applications spanning several domains of biomedical research.

1. Reproductive Endocrinology & HPG Axis Research

As the master regulator of the HPG axis, Kisspeptin-10 is an essential tool for studying the neuroendocrine control of reproduction. Research applications include:

• Puberty and Fertility: Investigating the role of the kisspeptin/GPR54 system in the onset of puberty and the regulation of fertility

• GnRH Neuroendocrine System: Studying how Kisspeptin-10 stimulates GnRH release through the Kiss1 receptor

• Gonadotropin Regulation: Exploring the dose‑dependent effects of Kisspeptin-10 on plasma LH, FSH, and testosterone

• Ovulation Induction: Evaluating the efficacy of Kisspeptin-10 compared with GnRH analogues

• Stress‑Induced Reproductive Dysfunction: Investigating the central mechanisms of Kisspeptin-10 in stress‑induced reproductive dysfunction

2. Bone Metabolism & Osteoclast Research

Kisspeptin-10 has emerged as a critical regulator of bone homeostasis. Research applications include:

• Osteoclast Activity Suppression: Kisspeptin-10 binding to GPR54 in osteoclasts prevents bone loss

• Therapeutic Target: The Kp‑10/GPR54 axis is a promising therapeutic target to abrogate bone resorption

3. Oncology & Metastasis Research

The KISS1 gene was first discovered as a metastasis suppressor gene. Kisspeptin-10 is a valuable tool for cancer research:

• Metastasis Suppression: Kisspeptin-10 inhibits metastasis and invasion in various cancers including gastric, pancreatic, ovarian, and prostate cancer

• Tumour Angiogenesis Inhibition: Kisspeptin-10 inhibits angiogenesis by suppressing Sp1‑mediated VEGF expression

• Diagnostic Imaging: Radionuclide‑labelled kisspeptin peptides provide a potential target for diagnostic imaging

4. Cardiovascular & Pulmonary Research

Emerging research has explored Kisspeptin-10’s effects beyond the reproductive axis:

• Pulmonary Arterial Hypertension: Kisspeptin-10 attenuates experimental PAH by recovering mitochondrial homeostasis and limiting aberrant mitophagy

• Cardiac Fibroblast Research: Kisspeptin-10 regulates glycosaminoglycan and decorin content in human cardiac fibroblast cultures at concentrations of 10⁻⁹ to 10⁻⁸ mol/L

5. Neuroendocrinology & Behavioural Research

Emerging research has explored Kisspeptin-10’s effects beyond the HPG axis:

• Antidepressant‑Like Effects: The antidepressant‑like effects of Kisspeptin-10 are reversed by a kisspeptin antagonist, suggesting a role in mood regulation

• Cerebral Aneurysm Prevention: The Kisspeptin‑10/GPR54 signalling pathway is dysregulated in individuals with cerebral aneurysms, and KP‑10 administration prevents their formation in mouse models

Chemical & Physical Specifications for Kisspeptin-10 (10mg)

Accurate characterisation of Kisspeptin-10 (10mg) research peptide is essential for reproducible experimental design.

Note: The 10 mg mass refers to the weight of the peptide in its lyophilised form. Kisspeptin-10 is typically supplied as a TFA or acetate salt, which enhances aqueous solubility. The C‑terminal amide is essential for biological activity.

Reconstitution & Handling Protocol for Kisspeptin-10 (10mg)

Proper reconstitution of Kisspeptin-10 (10mg) research peptide is critical for maintaining its structural integrity and biological activity. The peptide has a very rapid clearance in vivo, so careful handling is essential.

Step 1 – Preparation

• Bring the sealed Kisspeptin-10 vial and your chosen diluent (sterile bacteriostatic water or sterile PBS, pH 5‑7) to room temperature. Condensation can degrade the lyophilised powder.

• Clean your work surface with 70% ethanol and lay out sterile syringes, alcohol wipes and a clean work mat.

Step 2 – Vial Sanitisation

• Wipe the rubber stopper of the Kisspeptin-10 vial with a fresh 70% ethanol wipe. Allow the alcohol to evaporate completely before piercing.

Step 3 – Reconstitution

• Draw your desired volume of diluent into a sterile syringe. A common starting concentration for research applications is 10 mg per 1 mL of diluent, yielding a 10 mg/mL stock solution.

• Insert the needle and slowly inject the diluent against the inner glass wall. Do not spray directly onto the lyophilised powder.

• Gently swirl the vial until the solution is clear and fully dissolved. Do not shake vigorously, as shaking can cause denaturation.

Step 4 – Aliquoting & Storage

• Immediately after dissolution, aliquot the reconstituted Kisspeptin-10 into single‑use sterile vials.

• Store aliquots at –20°C. Avoid repeated freeze‑thaw cycles, as peptides are susceptible to degradation.

• Once thawed, store at 2‑8°C and use within a short period.

Concentration Reference Table for Kisspeptin-10 (10mg)

Adjust diluent volume based on your experimental requirements. For cell culture applications, typical working concentrations range from 0.1‑10 µM.

Storage & Stability Guidelines for Kisspeptin-10 (10mg)

Why Choose Chinese Grey Peptides for Kisspeptin-10 (10mg)?

As an authentic licensed peptide supplier based in the USA, we supply Kisspeptin-10 (10mg) research peptide and a wide range of research‑grade compounds under rigorous quality assurance protocols, fully aligned with Google’s E‑E‑A‑T standards (Experience, Expertise, Authoritativeness, Trustworthiness).

• Verified Purity: Independent HPLC analysis with purity guaranteed ≥98% for every batch.

• GMP‑Compliant Manufacturing: All peptides are synthesised under strict quality control conditions.

• Full Traceability: Batch‑specific Certificates of Analysis (COA) are available for every order.

• Wholesale Supply: We serve research institutions, laboratories, and wholesale buyers across the UK, EU, and USA with flexible volume pricing and reliable logistics.

• USA‑Based Regulatory Compliance: All products are supplied strictly as research‑grade chemicals for laboratory use only (RUO). This product is intended for scientific research and experimental use in controlled settings. Not for human or veterinary use.

Researchers across the United States—including those at leading institutions—trust us for fast domestic delivery, transparent documentation and professional technical support.

FAQ: Kisspeptin-10 (10mg) Research Peptide

What is Kisspeptin-10 (10mg) research peptide?
Kisspeptin-10 (KP-10, Metastin 45-54) is a decapeptide derived from the KISS1 gene product and the endogenous ligand for the Kisspeptin receptor (KISS1, GPR54). It is a master regulator of the hypothalamic-pituitary-gonadal (HPG) axis and also functions as a metastasis suppressor and regulator of bone metabolism.

What is the sequence and molecular weight of Kisspeptin-10?
The sequence is Tyr‑Asn‑Trp‑Asn‑Ser‑Phe‑Gly‑Leu‑Arg‑Phe‑NH₂ (YNWNSFGLRF-NH₂). Its molecular weight is approximately 1,302.4‑1,302.45 g/mol.

What are the primary research applications for Kisspeptin-10?
Kisspeptin-10 is used in reproductive endocrinology and HPG axis research (puberty, fertility, gonadotropin regulation, ovulation induction), bone metabolism and osteoclast studies (preventing bone loss), oncology and metastasis research (suppressing metastasis and angiogenesis), cardiovascular and pulmonary research, and neuroendocrinology and behavioural research (antidepressant effects, cerebral aneurysm prevention).

 What is the mechanism of action of Kisspeptin-10?
Kisspeptin-10 binds with high affinity to the Kisspeptin receptor (GPR54/KISS1R) with Ki values of 1.59 nM and 2.33 nM for rat and human receptors, respectively. This activation stimulates the release of LHRH from the hypothalamus, driving LH and FSH secretion. It also exerts direct pituitary effects, suppresses osteoclast activity, and inhibits tumour angiogenesis and metastasis.

What is the binding affinity of Kisspeptin-10 for KISS1R?
Kisspeptin-10 binds with high affinity to rat and human KISS1 receptors with Ki values of 1.59 nM and 2.33 nM, respectively. It exhibits approximately 8‑fold higher binding affinity compared to full‑length metastin.

What purity does your Kisspeptin-10 (10mg) meet?
Our Kisspeptin-10 is tested to ≥98% purity by HPLC. A Certificate of Analysis (COA) is supplied with every order.

How should I reconstitute Kisspeptin-10 (10mg)?
Reconstitute with sterile bacteriostatic water or sterile PBS (pH 5‑7). Allow the vial to reach room temperature, then slowly inject the diluent against the inner glass wall and swirl gently. Do not shake. A typical starting concentration is 10 mg/mL.

How should I store reconstituted Kisspeptin-10?
Reconstituted Kisspeptin-10 should be stored at 2‑8°C for short‑term use. For longer storage, aliquot immediately into single‑use vials and store at –20°C for up to 3 months. Avoid repeated freeze‑thaw cycles.

 Is Kisspeptin-10 research peptide legal to purchase in the USA?
Yes. Kisspeptin-10 is a laboratory reagent sold for research use only (RUO). It is fully legal to purchase, possess, and use in the United States for legitimate in‑vitro or in‑vivo scientific research, provided it is not marketed with therapeutic claims.

Does Chinese Grey Peptides ship internationally?
Yes. We ship across the UK, Europe (France, Germany, Spain, Sweden, Italy), and the USA from our US warehouse. Wholesale pricing is available for bulk orders.

1. Shop Page
2. Bulk Orders Page
3. Contact Page
4. Shipping & Return Page
5. Peptide Purity Page

• PubChem Kisspeptin-10
• IUPHAR Kisspeptin-10 ligand page
• FDA compounding-risk page for Kisspeptin-10
• Google Product Structured Data

Ships to USA, Canada, UK & Europe

Chinese Grey Peptides supports shipping to the USA, Canada, the United Kingdom, France, Germany, Spain, Sweden, Italy, and Europe where permitted.

Shipping support may include:

• Order processing updates
• Packaging support
• Tracking information where available
• Wholesale shipment planning
• Destination-based shipping review
• Customer support during transit

Shipping times may vary by order size, carrier, destination, customs process, product status, and local requirements.

Why Choose Chinese Grey Peptides?

Chinese Grey Peptides focuses on quality, support, and clear communication. We help buyers review product details before placing an order.

Customers choose us for:

• Professional peptide supplier support
• Small and wholesale order options
• Product documentation support
• HPLC testing information where available
• Mass Spectrum documentation where available
• International shipping support
• Responsive communication
• Clear order assistance before payment

We aim to make the buying process transparent, professional, and documentation-focused.

Important Compliance Notice

Kisspeptin-10 10mg may be regulated differently depending on the country, product type, labeling, intended use, buyer type, and destination. Chinese Grey Peptides does not provide medical advice, dosing instructions, injection guidance, hormone guidance, fertility claims, endocrine claims, reproductive-health claims, disease claims, treatment claims, athletic-performance claims, bodybuilding claims, or personal-use recommendations.

Customers are responsible for understanding and following all local laws, import rules, prescription requirements, compounding rules, sport-governing rules, labeling rules, advertising rules, and permitted-use requirements before ordering.

From its discovery as the endogenous ligand for GPR54 to its well‑characterised role as a master regulator of the HPG axis, a suppressor of metastasis, and a regulator of bone metabolism, Kisspeptin-10 (10mg) research peptide provides a precisely defined and extensively validated platform for advanced endocrinological, oncological, and bone biology research.

Its high‑affinity receptor binding (Ki = 1.59 nM for rat, 2.33 nM for human KISS1 receptors), ability to stimulate the HPG axis via LHRH release, and diverse downstream effects—supported by a growing body of peer‑reviewed literature published in PubMed, Nature Communications, and other authoritative journals—makes it a valuable addition to any laboratory investigating reproductive endocrinology, neuroendocrine signalling, metastasis suppression, or bone homeostasis. By choosing high‑purity, lab‑verified Kisspeptin-10 (10mg) research peptide from Chinese Grey Peptides, you ensure that your research is built on a foundation of quality, reproducibility, and scientific integrity.

Ready to advance your research with Kisspeptin-10 (10mg)? Browse our product catalogue, request a wholesale quote, or contact our support team today to discuss your laboratory’s specific needs. Place your order now and receive GMP‑grade Kisspeptin-10 delivered directly to your facility in the USA, UK, or Europe.