Ipamorelin (5mg) Research Peptide: A Selective Ghrelin Receptor Agonist for GH & Metabolic Studies

If your research investigates growth hormone (GH) secretion, muscle biology, or the pharmacological modulation of the ghrelin receptor, Ipamorelin (5mg) research peptide offers a precisely defined and extensively validated synthetic tool. Ipamorelin is a synthetic pentapeptide and a selective agonist of the growth hormone secretagogue receptor (GHSR-1a), also known as the ghrelin receptor. It was first described in 1998 as the first selective growth hormone secretagogue, distinguished by its ability to stimulate GH release without significantly elevating cortisol, adrenocorticotropic hormone (ACTH), or prolactin. This selectivity, combined with a plasma clearance rate five times lower than that of GHRP-6, positions Ipamorelin (5mg) research peptide as a valuable tool for laboratories investigating endocrine signalling, muscle growth, bone metabolism, and tissue repair.

At Chinese Grey Peptides, we supply high‑purity Ipamorelin (5mg) research peptide to research institutions and wholesale buyers across the United Kingdom, France, Germany, Spain, Sweden, Italy, and the USA. Every batch is lyophilised, HPLC‑verified to ≥98% purity, and accompanied by a Certificate of Analysis (COA), ensuring your investigations into GH regulation, muscle physiology, and receptor pharmacology begin with uncompromising quality.

What Is Ipamorelin and How Does It Work?

To fully appreciate the research potential of Ipamorelin (5mg) research peptide, it is essential to understand its biochemical design and the precise mechanism by which it exerts its selective effects.

The Selective Pentapeptide

Ipamorelin is a synthetic pentapeptide with the sequence Aib-His-D-2-Nal-D-Phe-Lys-NH₂. Its molecular formula is C₃₈H₄₉N₉O₅, and its molecular weight is approximately 711.9 g/mol. It has a CAS number of 170851-70-4. The peptide is a ghrelin mimetic that was derived from GHRP-1, and its structure incorporates D-amino acids that confer enhanced resistance to enzymatic degradation, contributing to its favourable pharmacokinetic profile.

Mechanism of Action: Selective GHSR-1a Agonism

The biological activity of Ipamorelin (5mg) research peptide is mediated through its selective activation of the growth hormone secretagogue receptor (GHSR-1a):

• Receptor Binding: Ipamorelin binds with high affinity to GHSR-1a (Ki = 63.4 nM), the same receptor targeted by the endogenous peptide hormone ghrelin. This receptor is expressed in the hypothalamus, pituitary gland, and peripheral tissues.

• Signalling Cascade: Receptor activation initiates a signalling cascade primarily through the Gαq/11 pathway, leading to the activation of phospholipase C (PLC). PLC catalyses the hydrolysis of PIP₂ into IP₃ and DAG. IP₃ triggers the release of intracellular calcium, a key step in stimulating the secretion of growth hormone from the pituitary gland. Ipamorelin induces inositol-1,4,5-triphosphate (IP₃) accumulation in cells expressing GHS-R1a with an EC₅₀ of 46.9 nM.

• Pulsatile GH Release: Receptor activation triggers a signalling cascade that stimulates the synthesis and pulsatile release of growth hormone from the anterior pituitary gland. Ipamorelin induces GH release in primary rat pituitary cells with an EC₅₀ of 1.3 nM.

• Selectivity Profile: Ipamorelin’s defining pharmacological advantage is its selectivity for GH release. It stimulates GH without significantly elevating cortisol, ACTH, or prolactin, even at doses well above those required for GH stimulation. This selectivity distinguishes it from earlier secretagogues like GHRP-6 and GHRP-2 and makes it a cleaner tool for studying GH dynamics.

• Preserved Feedback Loop: Unlike exogenous GH administration, Ipamorelin preserves the body’s natural negative feedback loop, allowing for more physiological studies of GH regulation.

Research Note: The First Selective GHS

A 1998 paper in the European Journal of Endocrinology first described ipamorelin as “the first selective growth hormone secretagogue”. This foundational study established Ipamorelin as a compound of significant interest for future clinical development. Early studies showed that ipamorelin was the first GHRP not to stimulate cortisol significantly.

Key Research Applications for Ipamorelin (5mg)

Ipamorelin (5mg) research peptide is a versatile tool with applications spanning several domains of biomedical research.

1. Growth Hormone & Endocrine Research

As a potent and selective GH secretagogue, Ipamorelin is a valuable tool for studying the regulation of the GH/IGF-1 axis. Research applications include:

• Pulsatile GH Dynamics: Investigating the mechanisms of pulsatile GH release and its role in metabolic regulation.

• Receptor Pharmacology: Characterising the binding affinity (Ki = 63.4 nM), selectivity, and downstream signalling of GHS-R1a.

• Comparative Studies: Comparing Ipamorelin with other GH secretagogues such as GHRP-2, GHRP-6, and sermorelin.

• Endocrine Selectivity: Studying the molecular basis of Ipamorelin’s selectivity for GH over other pituitary hormones.

2. Muscle & Bone Research

Ipamorelin has been studied for its effects on muscle and bone tissue. Research applications include:

• Lean Muscle Growth: Ipamorelin (18-450 µg/animal) increases body weight and longitudinal bone growth in rats.

• Longitudinal Bone Growth: Studies have demonstrated that Ipamorelin induces longitudinal bone growth in rats.

• Satellite Cell Activation: Exploring how Ipamorelin activates IGF-1 signalling and satellite cell repair.

• Body Composition: Investigating the effects of Ipamorelin on body composition, including fat gain and muscular atrophy.

3. Gastrointestinal & Motility Research

Emerging research has explored Ipamorelin’s effects on gastrointestinal function. Research applications include:

• Gastric Emptying: It increases gastric emptying in a rat model of postoperative ileus induced by laparotomy and intestinal manipulation when administered at doses of 0.014 or 0.14 µmol/kg.

• Postoperative Ileus: Studying Ipamorelin’s potential to ameliorate symptoms in rodent models of postoperative ileus.

4. Tissue Repair & Regeneration Research

Ipamorelin has demonstrated potential in tissue repair and regeneration. Research applications include:

• Tissue Regeneration: Investigating Ipamorelin’s role in supporting tissue regeneration.

• Anabolic Effects: Exploring the peptide’s ability to promote anabolism and slow catabolism.

5. Receptor Signalling & Pharmacology Research

Ipamorelin serves as a reference standard for studying GHSR-1a pharmacology. Research applications include:

• Signal Transduction Studies: Dissecting the Gαq/11-PLC-IP₃-Ca²⁺ signalling pathway.

• Structure-Activity Relationship (SAR) Studies: Investigating how modifications to the Ipamorelin sequence affect receptor binding and activity.

Chemical & Physical Specifications for Ipamorelin (5mg)

Accurate characterisation of Ipamorelin (5mg) research peptide is essential for reproducible experimental design.

Note: The 5 mg mass refers to the weight of the peptide in its lyophilised form. Ipamorelin is typically supplied as an acetate salt, which enhances aqueous solubility. The peptide is for research use only.

Reconstitution & Handling Protocol for Ipamorelin (5mg)

Proper reconstitution of Ipamorelin (5mg) research peptide is critical for maintaining its structural integrity and biological activity.

Step 1 – Preparation

• Bring the sealed Ipamorelin vial and your chosen diluent (sterile bacteriostatic water or sterile PBS, pH 5‑7) to room temperature. Condensation can degrade the lyophilised powder.

• Clean your work surface with 70% ethanol and lay out sterile syringes, alcohol wipes and a clean work mat.

Step 2 – Vial Sanitisation

• Wipe the rubber stopper of the Ipamorelin vial with a fresh 70% ethanol wipe. Allow the alcohol to evaporate completely before piercing.

Step 3 – Reconstitution

• Draw your desired volume of diluent into a sterile syringe. A common starting concentration for research applications is 5 mg per 0.5 mL of diluent, yielding a 10 mg/mL stock solution.

• Insert the needle and slowly inject the diluent against the inner glass wall. Do not spray directly onto the lyophilised powder.

• Gently swirl the vial until the solution is clear and fully dissolved. Do not shake vigorously, as shaking can cause denaturation.

Step 4 – Aliquoting & Storage

• Immediately after dissolution, aliquot the reconstituted Ipamorelin into single‑use sterile vials.

• Store aliquots at –20°C. Avoid repeated freeze‑thaw cycles, as peptides are susceptible to degradation.

• Once thawed, store at 2‑8°C and use within 7 days.

Concentration Reference Table for Ipamorelin (5mg)

Adjust diluent volume based on your experimental requirements. For cell culture applications, typical working concentrations may range from 0.1‑10 µM.

Storage & Stability Guidelines for Ipamorelin (5mg)

Why Choose Chinese Grey Peptides for Ipamorelin (5mg)?

As an authentic licensed peptide supplier based in the USA, we supply Ipamorelin (5mg) research peptide and a wide range of research‑grade compounds under rigorous quality assurance protocols, fully aligned with Google’s E‑E‑A‑T standards (Experience, Expertise, Authoritativeness, Trustworthiness).

• Verified Purity: Independent HPLC analysis with purity guaranteed ≥98% for every batch.

• GMP‑Compliant Manufacturing: All peptides are synthesised under strict quality control conditions.

• Full Traceability: Batch‑specific Certificates of Analysis (COA) are available for every order.

• Wholesale Supply: We serve research institutions, laboratories, and wholesale buyers across the UK, EU, and USA with flexible volume pricing and reliable logistics.

• USA‑Based Regulatory Compliance: All products are supplied strictly as research‑grade chemicals for laboratory use only (RUO).

Researchers across the United States—including those at leading institutions—trust us for fast domestic delivery, transparent documentation and professional technical support.

FAQ: Ipamorelin (5mg) Research Peptide

 What is Ipamorelin (5mg) research peptide?
Ipamorelin is a synthetic pentapeptide and a selective agonist of the growth hormone secretagogue receptor (GHSR-1a). It stimulates pulsatile GH release from the pituitary without significantly elevating cortisol, ACTH, or prolactin.

 What is the sequence and molecular weight of Ipamorelin?
The sequence is Aib-His-D-2-Nal-D-Phe-Lys-NH₂. Its molecular formula is C₃₈H₄₉N₉O₅, and its molecular weight is approximately 711.9 g/mol.

What are the primary research applications for Ipamorelin?
Ipamorelin is used in growth hormone and endocrine research (pulsatile GH dynamics, receptor pharmacology), muscle and bone research (lean muscle growth, longitudinal bone growth), gastrointestinal and motility research, tissue repair and regeneration studies, and receptor signalling and pharmacology research.

 What is the mechanism of action of Ipamorelin?
Ipamorelin binds selectively to GHSR-1a (Ki = 63.4 nM), activating a Gαq/11-PLC-IP₃-Ca²⁺ signalling cascade that stimulates pulsatile GH release. Its defining pharmacological advantage is GH stimulation without elevating cortisol, ACTH, or prolactin.

How does Ipamorelin differ from other GHRPs in research?
Ipamorelin is the first selective growth hormone secretagogue. Unlike GHRP-6 and GHRP-2, it does not significantly elevate cortisol, ACTH, or prolactin. It also has a plasma clearance rate five times lower than that of GHRP-6.

 What purity does your Ipamorelin (5mg) meet?
Our Ipamorelin is tested to ≥98% purity by HPLC. A Certificate of Analysis (COA) is supplied with every order.

 How should I reconstitute Ipamorelin (5mg)?
Reconstitute with sterile bacteriostatic water or sterile PBS (pH 5‑7). Allow the vial to reach room temperature, then slowly inject the diluent against the inner glass wall and swirl gently. Do not shake. A typical starting concentration is 10 mg/mL.

 How should I store reconstituted Ipamorelin?
Reconstituted Ipamorelin should be stored at 2‑8°C and used within 7 days. For longer storage, aliquot immediately into single‑use vials and store at –20°C for up to 3 months. Avoid repeated freeze‑thaw cycles.

 Is Ipamorelin research peptide legal to purchase in the USA?
Yes. Ipamorelin is a laboratory reagent sold for research use only (RUO). It is fully legal to purchase, possess, and use in the United States for legitimate in‑vitro or in‑vivo scientific research, provided it is not marketed with therapeutic claims.

Does Chinese Grey Peptides ship internationally?
Yes. We ship across the UK, Europe (France, Germany, Spain, Sweden, Italy), and the USA from our US warehouse. Wholesale pricing is available for bulk orders.

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From its discovery as the first selective growth hormone secretagogue to its well‑characterised role as a potent GHSR-1a agonist, Ipamorelin (5mg) research peptide provides a precisely defined and increasingly valuable platform for advanced endocrinological and metabolic research. Its ability to stimulate pulsatile GH release without elevating cortisol, ACTH, or prolactin—supported by foundational research published in the European Journal of Endocrinology and subsequent peer‑reviewed studies—makes it a valuable addition to any laboratory investigating GH regulation, muscle biology, or receptor pharmacology. By choosing high‑purity, lab‑verified Ipamorelin (5mg) research peptide from Chinese Grey Peptides, you ensure that your research is built on a foundation of quality, reproducibility, and scientific integrity.

Ready to advance your research with Ipamorelin (5mg)? Browse our product catalogue, request a wholesale quote, or contact our support team today to discuss your laboratory’s specific needs. Place your order now and receive GMP‑grade Ipamorelin delivered directly to your facility in the USA, UK, or Europe.