AOD 9604 (5mg) Research Peptide: A Lipolytic Fragment for Metabolic & Regenerative Studies

If your research investigates lipid metabolism, adipocyte signalling, or the molecular mechanisms of fat breakdown and tissue regeneration, AOD 9604 (5mg) research peptide — also known as GH Fragment 176‑191 — offers a precisely defined synthetic tool. This 15‑amino‑acid peptide corresponds to a modified fragment of the C‑terminal region of human growth hormone (hGH fragment 176‑191), specifically engineered to isolate the metabolic and lipolytic properties of the parent molecule.

Unlike full‑length HGH, this fragment selectively mimics the fat‑burning effects of HGH without activating growth hormone receptors or significantly impacting insulin or IGF‑1 levels. As a result, it stimulates lipolysis (fat breakdown) and inhibits lipogenesis (fat storage) without the adverse effects on blood sugar or growth. This makes AOD 9604 (5mg) research peptide a valuable tool for laboratories investigating lipid metabolism, obesity, adipocyte signalling, metabolic regulation, cartilage repair, and tissue regeneration.

At Chinese Grey Peptides, we supply high‑purity AOD 9604 (5mg) research peptide to research institutions and wholesale buyers across the United Kingdom, France, Germany, Spain, Sweden, Italy, and the USA. Every batch is lyophilised, HPLC‑verified to high purity, and accompanied by a Certificate of Analysis (COA), ensuring your investigations into lipid metabolism, fat oxidation, and tissue regeneration begin with uncompromising quality.

What Is AOD 9604 and How Does It Work?

To fully appreciate the research potential of AOD 9604 (5mg) research peptide, it is essential to understand its biochemical structure and the mechanisms by which it exerts its effects.

The 15‑Amino‑Acid C‑Terminal Fragment

AOD‑9604 (Anti‑Obesity Drug 9604) is a synthetic peptide consisting of 15 amino acids that corresponds to a modified fragment of the C‑terminal region of human growth hormone (hGH fragment 176‑191). Its sequence is H‑Tyr‑Leu‑Arg‑Ile‑Val‑Gln‑Cys‑Arg‑Ser‑Val‑Glu‑Gly‑Ser‑Cys‑Gly‑Phe‑OH. The peptide has a molecular formula of C₇₈H₁₂₃N₂₃O₂₃S₂ and a molecular weight of approximately 1815.12 Da. It has a CAS number of 221231‑10‑3. The peptide contains an intramolecular disulfide bond between Cys7 and Cys14, creating a cyclic loop that contributes to its biological activity and structural stability. Unlike full‑length HGH, AOD‑9604 does not bind to the growth hormone receptor or elevate IGF‑1 levels.

Mechanism of Action: Selective Lipolytic Signalling

The biological activity of AOD 9604 (5mg) research peptide is mediated through its selective interaction with metabolic pathways. The peptide appears to act through beta‑3 adrenergic receptor modulation in adipose tissue, working directly at the level of fat cells:

• Stimulation of Lipolysis: The peptide promotes the breakdown of stored triglycerides into free fatty acids available for energy use.

• Inhibition of Lipogenesis: It suppresses the formation of new fat storage from dietary substrates.

• Receptor‑Independent Effects: Unlike full‑length HGH, AOD‑9604 does not significantly interact with growth hormone receptors associated with growth‑promoting pathways. It selectively mimics the lipolytic activity of HGH without the accompanying hyperglycemia or IGF‑1 elevation.

• Cartilage and Tissue Research: Some experimental research suggests the peptide may influence cartilage metabolism and tissue repair pathways.

Key Research Applications for AOD 9604 (5mg)

AOD 9604 (5mg) research peptide is a versatile tool with applications spanning several domains of biomedical research.

1. Lipid Metabolism & Adipocyte Research

As a peptide that selectively stimulates lipolysis and inhibits lipogenesis, AOD‑9604 is a valuable tool for studying fat metabolism. Research applications include:

• Lipolysis Signalling Pathways: Investigating the molecular mechanisms that trigger the breakdown of triglycerides in adipocytes, with evidence suggesting a role for the β3‑adrenergic pathway.

• Adipocyte Metabolism: Studying the regulation of lipid storage and mobilisation in adipose tissue.

• Lipid Accumulation: Exploring how the peptide inhibits lipid accumulation in adipocytes.

2. Obesity & Metabolic Disorder Research

Because the peptide influences fat metabolism pathways, it is frequently used in experimental models studying metabolic diseases and obesity. Research applications include:

• Adipose Tissue Regulation: Studying the metabolic regulation of adipose tissue.

• Obesity Development: Investigating the mechanisms of obesity development.

• Metabolic Syndrome: Exploring adipocyte differentiation and signalling in metabolic syndrome models.

3. Cartilage & Joint Research

AOD‑9604 has demonstrated potential in cartilage repair and joint recovery research. Research applications include:

• Cartilage Regeneration: Studies have shown that AOD‑9604 enhances cartilage regeneration in a rabbit model of collagenase‑induced knee osteoarthritis.

• Joint Recovery: Exploring the peptide’s impact on post‑injury recovery and inflammation modulation.

• Osteoarthritis Models: Investigating the peptide’s potential to mitigate degenerative joint conditions.

4. Endocrinology & Hormone Signalling Research

The fragment provides a useful model for studying the structure‑function relationship of growth hormone and identifying biologically active domains within peptide hormones:

• Hormone Functional Domains: Analysing the specific domains responsible for metabolic effects.

• Receptor‑Independent Effects: Studying peptide hormone signalling pathways independent of the GH receptor.

• Hormone‑Derived Therapeutics: Investigating peptide‑based approaches for modulating lipid metabolism.

5. Bone & Osteoporosis Research

AOD‑9604 has been investigated for its effects on bone metabolism and osteoporosis. Research applications include:

• Bone Remodelling: Studying the modulation of osteoblast and osteoclast activity. The peptide seems to provide a framework for studying bone formation and resorption mechanisms.

• Osteoporosis Models: Investigating the potential of AOD‑9604 in the aged rat model of postmenopausal osteoporosis.

Chemical & Physical Specifications for AOD 9604 (5mg)

Accurate characterisation of AOD 9604 (5mg) research peptide is essential for reproducible experimental design.

Note: The 5 mg mass refers to the weight of the peptide in its lyophilised form. AOD‑9604 is typically supplied as an acetate salt. The peptide is for research use only (RUO). Not for human consumption. AOD‑9604 is not FDA‑approved for therapeutic use and is restricted by the World Anti‑Doping Agency (WADA) for athletic use.

Reconstitution & Handling Protocol for AOD 9604 (5mg)

Proper reconstitution of AOD 9604 (5mg) research peptide is critical for maintaining its structural integrity and biological activity. The peptide has a half‑life of approximately 30‑60 minutes (oral); shorter for IV/SC.

Step 1 – Preparation

• Bring the sealed AOD‑9604 vial and your chosen diluent (sterile bacteriostatic water or sterile PBS, pH 5‑7) to room temperature. Condensation can degrade the lyophilised powder.

• Clean your work surface with 70% ethanol and lay out sterile syringes, alcohol wipes and a clean work mat.

Step 2 – Vial Sanitisation

• Wipe the rubber stopper of the AOD‑9604 vial with a fresh 70% ethanol wipe. Allow the alcohol to evaporate completely before piercing.

Step 3 – Reconstitution

• Draw your desired volume of diluent into a sterile syringe. A common starting concentration for research applications is 5 mg per 0.5 mL of diluent, yielding a 10 mg/mL stock solution.

• Insert the needle and slowly inject the diluent against the inner glass wall. Do not spray directly onto the lyophilised powder.

• Gently swirl the vial until the solution is clear and fully dissolved. Do not shake vigorously, as shaking can cause denaturation.

Step 4 – Aliquoting & Storage

• Immediately after dissolution, aliquot the reconstituted AOD‑9604 into single‑use sterile vials.

• Store aliquots at –20°C. Avoid repeated freeze‑thaw cycles, as peptides are susceptible to degradation.

• Once thawed, store at 2‑8°C and use within 1 month.

Concentration Reference Table

Adjust diluent volume based on your experimental requirements. For cell culture applications, typical working concentrations may range from 0.1‑10 µM.

Storage & Stability Guidelines

Why Choose Chinese Grey Peptides for AOD 9604 (5mg)?

As an authentic licensed peptide supplier based in the USA, we supply AOD 9604 (5mg) research peptide and a wide range of research‑grade compounds under rigorous quality assurance protocols, fully aligned with Google’s E‑E‑A‑T standards (Experience, Expertise, Authoritativeness, Trustworthiness).

• Verified Purity: Independent HPLC analysis with purity guaranteed ≥98% for every batch.

• GMP‑Compliant Manufacturing: All peptides are synthesised under strict quality control conditions.

• Full Traceability: Batch‑specific Certificates of Analysis (COA) are available for every order.

• Wholesale Supply: We serve research institutions, laboratories, and wholesale buyers across the UK, EU, and USA with flexible volume pricing and reliable logistics.

• USA‑Based Regulatory Compliance: All products are supplied strictly as research‑grade chemicals for laboratory use only (RUO). AOD‑9604 is not FDA‑approved for therapeutic use and is restricted by WADA for athletic use.

Researchers across the United States—including those at leading institutions—trust us for fast domestic delivery, transparent documentation and professional technical support.

FAQ: AOD 9604 (5mg) Research Peptide

What is AOD 9604 (5mg) research peptide?
AOD‑9604 (Anti‑Obesity Drug 9604, GH Fragment 176‑191) is a synthetic 15‑amino‑acid peptide derived from the C‑terminal region of human growth hormone. It selectively mimics the lipolytic activity of HGH without activating growth hormone receptors or elevating IGF‑1 levels.

What is the sequence and molecular weight of AOD‑9604?
The sequence is H‑Tyr‑Leu‑Arg‑Ile‑Val‑Gln‑Cys‑Arg‑Ser‑Val‑Glu‑Gly‑Ser‑Cys‑Gly‑Phe‑OH. Its molecular weight is approximately 1815.12 Da.

What are the primary research applications for AOD‑9604?
AOD‑9604 is used in lipid metabolism and adipocyte research, obesity and metabolic disorder research, cartilage and joint research, endocrinology and hormone signalling studies, and bone and osteoporosis research.

 What is the mechanism of action of AOD‑9604?
The peptide stimulates lipolysis (breakdown of stored fat) and inhibits lipogenesis (formation of new fat). It appears to act through beta‑3 adrenergic receptor modulation in adipose tissue. Unlike full‑length HGH, it does not activate GH receptors or elevate IGF‑1 levels.

 What purity does your AOD 9604 (5mg) meet?
Our AOD‑9604 is tested to ≥98% purity by HPLC. A Certificate of Analysis (COA) is supplied with every order.

 How should I reconstitute AOD 9604 (5mg)?
Reconstitute with sterile bacteriostatic water or sterile PBS (pH 5‑7). Allow the vial to reach room temperature, then slowly inject the diluent against the inner glass wall and swirl gently. Do not shake. A typical starting concentration is 10 mg/mL.

How should I store reconstituted AOD‑9604?
Reconstituted AOD‑9604 should be stored at 2‑8°C for short‑term use. For longer storage, aliquot immediately into single‑use vials and store at –20°C for up to 1 month or at –80°C for up to 6 months. Avoid repeated freeze‑thaw cycles.

Is AOD‑9604 research peptide legal to purchase in the USA?
Yes. AOD‑9604 is a laboratory reagent sold for research use only (RUO). It is fully legal to purchase, possess, and use in the United States for legitimate in‑vitro or in‑vivo scientific research, provided it is not marketed with therapeutic claims. Note: AOD‑9604 is not FDA‑approved and is restricted by the World Anti‑Doping Agency (WADA) for athletic use.

 Does Chinese Grey Peptides ship internationally?
Yes. We ship across the UK, Europe (France, Germany, Spain, Sweden, Italy), and the USA from our US warehouse. Wholesale pricing is available for bulk orders.

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Ships to USA, Canada, UK & Europe

Chinese Grey Peptides supports shipping to the USA, Canada, the United Kingdom, France, Germany, Spain, Sweden, Italy, and Europe where permitted.

Shipping support may include:

• Order processing updates
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• Tracking information where available
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Shipping times may vary by order size, carrier, destination, customs process, product status, and local requirements.

Why Choose Chinese Grey Peptides?

Chinese Grey Peptides focuses on quality, support, and clear communication. We help buyers review product details before placing an order.

Customers choose us for:

• Professional peptide supplier support
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• HPLC testing information where available
• Mass Spectrum documentation where available
• International shipping support
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We aim to make the buying process transparent, professional, and documentation-focused.

Important Compliance Notice

AOD 9604 5mg may be regulated differently depending on the country, product type, labeling, intended use, buyer type, and destination. Chinese Grey Peptides does not provide medical advice, dosing instructions, injection guidance, fat-loss claims, athletic-performance claims, bodybuilding claims, growth hormone claims, anti-aging claims, disease claims, treatment claims, or personal-use recommendations.

Customers are responsible for understanding and following all local laws, import rules, prescription requirements, compounding rules, sport-governing rules, and permitted-use requirements before ordering.

From its design as a selectively engineered fragment of human growth hormone to its well‑characterised role in promoting lipolysis, inhibiting lipogenesis, and supporting cartilage repair, AOD 9604 (5mg) research peptide provides a precisely defined and increasingly valuable platform for advanced metabolic and regenerative research.

Its ability to stimulate fat oxidation without activating GH receptors or impacting IGF‑1 levels—supported by peer‑reviewed research published in the Journal of Endocrinology, Regulatory Toxicology and Pharmacology, and other authoritative journals—makes it a valuable addition to any laboratory investigating lipid metabolism, obesity, cartilage repair, or tissue regeneration. By choosing high‑purity, lab‑verified AOD 9604 (5mg) research peptide from Chinese Grey Peptides, you ensure that your research is built on a foundation of quality, reproducibility, and scientific integrity.

Ready to advance your research with AOD 9604 (5mg)? Browse our product catalogue, request a wholesale quote, or contact our support team today to discuss your laboratory’s specific needs. Place your order now and receive GMP‑grade AOD‑9604 delivered directly to your facility in the USA, UK, or Europe.