Adipotide (FTPP) (10mg) Research Peptide: A Targeted Proapoptotic Agent for Adipose & Vascular Studies

If your research investigates adipose tissue biology, vascular targeting, or the molecular mechanisms underlying selective tissue ablation, Adipotide (FTPP) (10mg) research peptide offers a uniquely designed synthetic tool with a well‑characterised mechanism of action.

Also known as FTPP (Fat‑Targeted Proapoptotic Peptide), Prohibitin‑Targeting Peptide‑1 (Prohibitin‑TP01), and HKPao, Adipotide is a bipartite peptidomimetic consisting of a vascular homing domain (CKGGRAKDC) fused to a proapoptotic effector sequence (D(KLAKLAK)₂). The homing domain binds selectively to the prohibitin‑annexin A2 complex expressed on the luminal surface of endothelial cells supplying white adipose tissue, while the proapoptotic domain disrupts mitochondrial membranes upon internalisation, leading to targeted apoptosis of adipose vasculature. This unique mechanism — which bypasses appetite and metabolism to act directly on fat tissue — has made Adipotide (FTPP) (10mg) research peptide a valuable tool for laboratories investigating obesity, metabolic disorders, angiogenesis, and the broader implications of ligand‑directed vascular targeting.

At Chinese Grey Peptides, we supply high‑purity Adipotide (FTPP) (10mg) research peptide to research institutions and wholesale buyers across the United Kingdom, France, Germany, Spain, Sweden, Italy, and the USA. Every batch is lyophilised, HPLC‑verified to >99% purity, and accompanied by a Certificate of Analysis (COA), ensuring your investigations into adipose biology, vascular targeting, and metabolic regulation begin with uncompromising quality.

What Is Adipotide (FTPP) and How Does It Work?

To fully appreciate the research potential of Adipotide (FTPP) (10mg) research peptide, it is essential to understand its biochemical design and the precise mechanism by which it exerts its effects.

The Bipartite Peptidomimetic Structure

Adipotide is a synthetic chimeric peptidomimetic compound originally developed through in vivo phage display peptide library screening at MD Anderson Cancer Center by Kolonin, Pasqualini, Arap, and colleagues. It consists of two functional domains connected by a glycine‑glycine linker:

• Homing Domain (CKGGRAKDC): A 9‑amino‑acid cyclic peptide with an intramolecular disulfide bond between the two terminal cysteine residues. This motif was isolated through phage‑display screening for peptides that home selectively to white adipose vasculature. It binds to the prohibitin‑annexin A2 (PHB‑ANXA2) receptor complex expressed on the luminal surface of endothelial cells in blood vessels supplying white adipose tissue.

• Proapoptotic Domain (D(KLAKLAK)₂): A 14‑amino‑acid sequence synthesised using D‑amino acids (the mirror‑image enantiomers of naturally occurring L‑amino acids). This amphipathic peptide adopts an alpha‑helical conformation that disrupts mitochondrial membranes upon internalisation, triggering apoptosis of targeted endothelial cells.

Mechanism of Action: Vascular Targeting and Endothelial Apoptosis

The biological activity of Adipotide (FTPP) (10mg) research peptide is mediated through a sequence of well‑defined events:

• Selective Receptor Binding: The homing domain binds specifically to the prohibitin‑annexin A2 complex on the surface of endothelial cells in white adipose tissue vasculature. This receptor complex is enriched on adipose vasculature and plays a role in fatty acid transport.

• Internalisation and Mitochondrial Disruption: Upon binding, the peptide is internalised. The D(KLAKLAK)₂ effector domain disrupts mitochondrial membranes, triggering programmed cell death (apoptosis) in the targeted endothelial cells.

• Vascular Ablation and Secondary Adipocyte Death: The apoptotic death of adipose vasculature leads to the collapse of the microvasculature supplying white adipocytes. Without adequate blood flow, the adipocytes undergo ischaemic injury and subsequently die. The dead adipose cells are then reabsorbed and cleared by the research model’s immune system.

• Fatty Acid Transport Modulation: Beyond vascular targeting, Adipotide’s mechanism is intertwined with the roles of PHB and ANXA2 in fatty acid transport. Disruption of PHB‑ANXA2 binding appears to reduce fatty acid uptake into adipose depots, indirectly modulating lipid influx.

Research Note: Preclinical Evidence and Regulatory Status

Adipotide has demonstrated significant weight loss and metabolic improvements in preclinical models. In a landmark 2011 rhesus macaque study, treated animals lost approximately 10.6% of body weight over 28 days, with a 38.7% reduction in total body fat confirmed by MRI and DEXA. In obese mice, Adipotide reversed obesity within 27 days.

However, it is important to note that Adipotide is not FDA‑approved for human use and has no approved indication. A Phase 1 human clinical trial was initiated in 2012 but was ultimately discontinued due to dose‑dependent renal toxicity, including tubular necrosis and glomerular changes observed in primate studies. As of 2026, no peer‑reviewed human clinical data has been published. Adipotide is supplied strictly for in‑vitro and in‑vivo research use only.

Key Research Applications for Adipotide (FTPP) (10mg)

Adipotide (FTPP) (10mg) research peptide is a versatile tool with applications spanning several domains of biomedical research.

1. Adipose Tissue Biology & Obesity Research

As a peptide that selectively targets the vasculature of white adipose tissue, Adipotide is a valuable tool for studying adipose biology and obesity pathophysiology. Research applications include:

• Adipose Tissue Remodelling: Investigating how vascular ablation leads to adipose tissue mass reduction and altered adipocyte function.

• Subcutaneous vs. Visceral Fat: Exploring the differential targeting of subcutaneous and visceral fat depots.

• Energy Homeostasis: Studying the role of adipose vasculature in energy balance and metabolic regulation.

• White vs. Brown Adipose Tissue: Adipotide is selective for white adipose tissue (WAT) and does not target brown adipose tissue (BAT), which does not express the same vascular receptor markers.

2. Metabolic & Diabetes Research

Adipotide has demonstrated significant effects on metabolic parameters in preclinical models. Research applications include:

• Insulin Sensitivity: Adipotide treatment resulted in significantly improved insulin sensitivity and enhanced glucose tolerance in obese monkeys.

• Glucose Metabolism: The peptide may support glucose tolerance by reducing adipose tissue inflammation and supporting insulin receptor signalling.

• Type 2 Diabetes Models: Exploring the peptide’s potential as a research tool for understanding the relationship between adipose tissue and diabetes.

3. Angiogenesis & Vascular Research

Adipotide’s reliance on vascular disruption positions it as a research tool for exploring angiogenesis in adipose and other tissues. Research applications include:

• Vascular Remodelling: Studying vascular remodelling in response to metabolic demands.

• Endothelial Cell Biology: Investigating the role of prohibitin and annexin A2 in endothelial cell function and fatty acid transport.

• Adipose Vasculature: Exploring the unique properties of adipose tissue vasculature and its role in metabolic regulation.

4. Oncology & Cancer Research

Adipotide has been investigated for its potential applications in oncology. Research applications include:

• Prostate Cancer: Research indicates that destruction of white fat may have positive consequences for prostate cancer.

• Angiogenesis Inhibition: By inducing apoptosis in blood vessels, Adipotide might disrupt the vascular support of tumours, potentially inhibiting their growth.

• Obesity‑Associated Cancers: Studying the relationship between adipose tissue reduction and cancer progression.

5. Receptor Biology & Fatty Acid Transport Research

Adipotide serves as a valuable tool for studying the prohibitin‑annexin A2‑CD36 axis:

• Fatty Acid Transport: Investigating how PHB‑ANXA2‑CD36 complexes facilitate fatty acid uptake by the endothelium and subsequent transport into adipocytes.

• Receptor Pharmacology: Characterising the binding affinity and selectivity of ligands targeting the prohibitin‑annexin A2 complex.

• Signal Transduction: Dissecting the downstream signalling pathways affected by PHB‑ANXA2 disruption.

Chemical & Physical Specifications for Adipotide (FTPP) (10mg)

Accurate characterisation of Adipotide (FTPP) (10mg) research peptide is essential for reproducible experimental design.

Note: The 10 mg mass refers to the weight of the peptide in its lyophilised form. Adipotide is typically supplied as an acetate salt. The peptide contains a disulfide bridge in the homing domain (Cys1‑Cys9) and D‑amino acids in the effector domain, which confer resistance to proteolytic degradation. Adipotide is not FDA‑approved for human use and is supplied strictly for research use only (RUO).

Reconstitution & Handling Protocol for Adipotide (FTPP) (10mg)

Proper reconstitution of Adipotide (FTPP) (10mg) research peptide is critical for maintaining its structural integrity and biological activity. The peptide is water‑soluble and can be dissolved in saline for in‑vivo use.

Step 1 – Preparation

• Bring the sealed Adipotide vial and your chosen diluent (sterile 0.9% saline or sterile PBS, pH 5‑7) to room temperature.

• Clean your work surface with 70% ethanol and lay out sterile syringes, alcohol wipes and a clean work mat.

Step 2 – Vial Sanitisation

• Wipe the rubber stopper of the Adipotide vial with a fresh 70% ethanol wipe. Allow the alcohol to evaporate completely before piercing.

Step 3 – Reconstitution

• Draw your desired volume of diluent into a sterile syringe. A common starting concentration for research applications is 10 mg per 1 mL of diluent, yielding a 10 mg/mL stock solution.

• Insert the needle and slowly inject the diluent against the inner glass wall. Do not spray directly onto the lyophilised powder.

• Gently swirl the vial until the solution is clear and fully dissolved. Do not shake vigorously, as shaking can cause denaturation.

Step 4 – Aliquoting & Storage

• Immediately after dissolution, aliquot the reconstituted Adipotide into single‑use sterile vials.

• Store aliquots at –20°C. Avoid repeated freeze‑thaw cycles, as peptides are susceptible to degradation.

• Once thawed, store at 2‑8°C and use within a short period.

Concentration Reference Table for Adipotide (FTPP) (10mg)

*Adjust diluent volume based on your experimental requirements. For research applications, typical doses in primate studies ranged from 0.5‑1.0 mg/kg/day.

Storage & Stability Guidelines for Adipotide (FTPP) (10mg)

Why Choose Chinese Grey Peptides for Adipotide (FTPP) (10mg)?

As an authentic licensed peptide supplier based in the USA, we supply Adipotide (FTPP) (10mg) research peptide and a wide range of research‑grade compounds under rigorous quality assurance protocols, fully aligned with Google’s E‑E‑A‑T standards (Experience, Expertise, Authoritativeness, Trustworthiness).

• Verified Purity: Independent HPLC analysis with purity guaranteed >99% for every batch.

• Sterile Filtration: Each batch is sterile‑filtered and lyophilised under GMP‑compliant conditions.

• Full Traceability: Batch‑specific Certificates of Analysis (COA) are available for every order.

• Wholesale Supply: We serve research institutions, laboratories, and wholesale buyers across the UK, EU, and USA with flexible volume pricing and reliable logistics.

• USA‑Based Regulatory Compliance: All products are supplied strictly as research‑grade reagents for laboratory use only (RUO). Adipotide is not FDA‑approved for human use and has no approved indication.

Researchers across the United States—including those at leading institutions—trust us for fast domestic delivery, transparent documentation and professional technical support.

FAQ: Adipotide (FTPP) (10mg) Research Peptide

What is Adipotide (FTPP) (10mg) research peptide?
Adipotide (FTPP, Prohibitin‑TP01, HKPao) is a synthetic bipartite peptidomimetic that selectively targets the vasculature of white adipose tissue via the prohibitin‑annexin A2 receptor complex. It comprises a homing domain (CKGGRAKDC) and a proapoptotic effector domain (D(KLAKLAK)₂).

What is the sequence and molecular weight of Adipotide?
The sequence is CKGGRAKDC‑GG‑(D‑KLAKLAK)₂. Its molecular weight is approximately 2,460 Da, with the acetate salt form having a molecular weight of approximately 2,617 Da.

What are the primary research applications for Adipotide?
Adipotide is used in adipose tissue biology and obesity research, metabolic and diabetes research (insulin sensitivity, glucose tolerance), angiogenesis and vascular research, oncology and cancer research, and receptor biology and fatty acid transport studies.

 What is the mechanism of action of Adipotide?
Adipotide binds to the prohibitin‑annexin A2 complex on adipose endothelial cells via its CKGGRAKDC targeting domain. Upon internalisation, the D(KLAKLAK)₂ effector domain disrupts mitochondrial membranes, triggering endothelial apoptosis. This cuts off the blood supply to white adipocytes, leading to fat cell death and adipose tissue reduction.

What preclinical evidence supports Adipotide’s efficacy?
In a 2011 rhesus macaque study, treated animals lost approximately 10.6% of body weight over 28 days, with a 38.7% reduction in total body fat. In obese mice, Adipotide reversed obesity within 27 days.

Q6: What purity does your Adipotide (FTPP) (10mg) meet?
Our Adipotide is tested to >99% purity by HPLC. A Certificate of Analysis (COA) is supplied with every order.

 How should I reconstitute Adipotide (FTPP) (10mg)?
Reconstitute with sterile 0.9% saline or sterile PBS (pH 5‑7). Allow the vial to reach room temperature, then slowly inject the diluent against the inner glass wall and swirl gently. Do not shake. A typical starting concentration is 10 mg/mL.

How should I store reconstituted Adipotide?
Reconstituted Adipotide should be stored at 2‑8°C for short‑term use. For longer storage, aliquot immediately into single‑use vials and store at –20°C for up to 3 months. Avoid repeated freeze‑thaw cycles.

Is Adipotide (FTPP) research peptide legal to purchase in the USA?
Yes. Adipotide is a laboratory reagent sold for research use only (RUO). It is fully legal to purchase, possess, and use in the United States for legitimate in‑vitro or in‑vivo scientific research, provided it is not marketed with therapeutic claims. Note: Adipotide is not FDA‑approved for human use, has no approved indication, and has no legal pathway for human use in the United States. A Phase 1 clinical trial was discontinued due to dose‑dependent renal toxicity.

 Does Chinese Grey Peptides ship internationally?
Yes. We ship across the UK, Europe (France, Germany, Spain, Sweden, Italy), and the USA from our US warehouse. Wholesale pricing is available for bulk orders.

Adipotide (FTPP) (10mg)

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• NCI Drug Dictionary: Prohibitin-targeting peptide 1
• PubMed Adipotide peptidomimetic paper
• PMC full-text Adipotide paper
• FDA Gram Peptides warning letter
• Google Product Structured Data
• Rank Math WooCommerce Product Schema

Adipotide (FTPP) (10mg)

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Adipotide (FTPP) (10mg)

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Adipotide FTPP 10mg may be regulated differently depending on the country, product type, labeling, intended use, buyer type, and destination. Chinese Grey Peptides does not provide medical advice, dosing instructions, injection guidance, fat-loss claims, weight-loss claims, obesity claims, metabolic claims, body-composition claims, bodybuilding claims, athletic-performance claims, disease claims, treatment claims, or personal-use recommendations.

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Adipotide (FTPP) (10mg)

From its origin as a phage‑display‑discovered homing peptide to its well‑characterised role in selectively targeting adipose vasculature, Adipotide (FTPP) (10mg) research peptide provides a precisely defined and mechanistically distinct platform for advanced adipose and metabolic research.

Its ability to induce endothelial apoptosis via the prohibitin‑annexin A2 receptor complex, thereby cutting off the blood supply to white adipocytes—supported by preclinical studies demonstrating significant weight loss and metabolic improvements in rodent and primate models—makes it a valuable addition to any laboratory investigating adipose tissue biology, obesity pathophysiology, vascular targeting, or metabolic regulation. By choosing high‑purity, lab‑verified Adipotide (FTPP) (10mg) research peptide from Chinese Grey Peptides, you ensure that your research is built on a foundation of quality, reproducibility, and scientific integrity.

Ready to advance your research with Adipotide (FTPP) (10mg)? Browse our product catalogue, request a wholesale quote, or contact our support team today to discuss your laboratory’s specific needs. Place your order now and receive GMP‑grade Adipotide delivered directly to your facility in the USA, UK, or Europe.