Mazdutide Research Peptide: A Potent Dual GLP‑1/Glucagon Receptor Agonist for Metabolic Studies

If your research investigates the intricate interplay between appetite regulation, energy expenditure, and glycaemic control, Mazdutide research peptide offers a precisely defined and mechanistically advanced synthetic tool. Also known as IBI‑362 and LY‑3305677, Mazdutide is a long‑acting synthetic analogue of the endogenous gut hormone oxyntomodulin, engineered as a dual agonist of the glucagon‑like peptide‑1 receptor (GLP‑1R) and the glucagon receptor (GCGR).

Unlike single‑receptor agonists, this balanced dual activation provides a comprehensive approach to metabolic research: GLP‑1R agonism suppresses appetite and enhances glucose‑dependent insulin secretion, while GCGR activation promotes energy expenditure and fatty acid oxidation. This makes Mazdutide research peptide an invaluable tool for laboratories investigating obesity, type 2 diabetes, metabolic dysfunction‑associated steatotic liver disease (MASLD), and the broader systemic effects of dual‑receptor signalling.

At Chinese Grey Peptides, we supply high‑purity Mazdutide research peptide to research institutions and wholesale buyers across the United Kingdom, France, Germany, Spain, Sweden, Italy, and the USA. Every batch is lyophilised, HPLC‑verified to ≥99% purity, and accompanied by a Certificate of Analysis (COA), ensuring your investigations into metabolic regulation, obesity, and diabetes research begin with uncompromising quality.

What Is Mazdutide and How Does It Work?

To fully appreciate the research potential of Mazdutide research peptide, it is essential to understand its biochemical design and the precise mechanisms by which it exerts its pleiotropic metabolic effects.

The Long‑Acting Oxyntomodulin Analogue

Mazdutide is a synthetic 34‑amino‑acid peptide derived from the natural hormone oxyntomodulin, which is co‑secreted with GLP‑1 from intestinal L‑cells. Its molecular formula is C₂₁₀H₃₂₂N₄₆O₆₇, with a molecular weight of approximately 4563.06‑4563.07 g/mol. It has a CAS number of 2259884‑03‑0 and a PubChem CID of 167312357.

The peptide incorporates a non‑coded amino acid (Aib) at position 2 to enhance proteolytic stability, and a C18 fatty diacid moiety conjugated via a linker to extend half‑life through albumin binding, supporting once‑weekly administration in clinical research. It is supplied as a lyophilised powder for research use only (RUO).

Mechanism of Action: Balanced Dual‑Receptor Agonism

The biological activity of Mazdutide research peptide is mediated through its potent and balanced activation of two distinct G‑protein‑coupled receptors:

• GLP‑1 Receptor (GLP‑1R) Activation: Mazdutide binds to GLP‑1R with a Ki of 28.6 nM (human), stimulating glucose‑dependent insulin secretion, suppressing appetite, and delaying gastric emptying. This pathway is well‑characterised for its role in glycaemic control and weight reduction.

• Glucagon Receptor (GCGR) Activation: Mazdutide binds to GCGR with a Ki of 17.7 nM (human), promoting energy expenditure, fatty acid oxidation, and thermogenesis. This pathway complements the GLP‑1 effects by increasing metabolic rate.

• Synergistic Metabolic Effects: The combination of GLP‑1R and GCGR activation produces synergistic effects on body weight and glycaemic control that are greater than those achieved with either pathway alone. Mazdutide stimulates insulin secretion from mouse islets with an EC₅₀ of 5.2 nM.

Research Note: A Clinically Validated Compound

Mazdutide has received regulatory approval in China at doses of 4 mg and 6 mg for weight management. In clinical trials evaluating doses up to 16 mg, mazdutide has demonstrated significant glycaemic control and weight reduction in people with type 2 diabetes, overweight, or obesity. A Phase 2 randomised controlled trial of 9 mg mazdutide in Chinese adults with obesity (BMI ≥30 kg/m²) without diabetes demonstrated substantial weight loss.

Key Research Applications for Mazdutide Research Peptide

Mazdutide research peptide is a versatile tool with applications spanning several domains of biomedical research.

1. Obesity & Weight Regulation Research

Mazdutide has demonstrated robust, dose‑dependent weight loss in clinical and preclinical models. Research applications include:

• Energy Balance Studies: Investigating how simultaneous GLP‑1R and GCGR activation modulates appetite, satiety, and energy expenditure.

• Weight Loss Mechanisms: Studying the molecular basis of weight reduction in diet‑induced obese (DIO) mouse models.

• Dose‑Response Studies: Characterising the dose‑dependent effects of mazdutide on body weight, waist circumference, and blood pressure.

2. Type 2 Diabetes Research

Mazdutide has demonstrated significant glycaemic control in clinical trials. Research applications include:

• Glycaemic Control Studies: Investigating the effects of mazdutide on HbA1c reduction. In a head‑to‑head Phase 3 trial, 48.0% of participants in the mazdutide group achieved both HbA1c <7% and ≥10% weight loss, compared to 21.0% for semaglutide.

• Insulin Sensitivity: Studying the role of GLP‑1R activation in enhancing glucose‑dependent insulin secretion.

• Comparative Studies: Comparing mazdutide with other GLP‑1 receptor agonists such as semaglutide and dulaglutide.

3. Metabolic Dysfunction‑Associated Steatotic Liver Disease (MASLD) Research

Mazdutide has demonstrated potent efficacy in hepatic metabolism models. Research applications include:

• Hepatic Fat Reduction: Investigating the effects of dual GLP‑1R/GCGR activation on systemic and hepatic metabolism in MAFLD models.

• Hepatic Lipid Metabolism: Studying how GCGR activation promotes fatty acid oxidation and reduces hepatic fat accumulation.

• Fibrosis Research: Exploring the potential anti‑fibrotic effects of dual agonism on hepatic tissue.

4. Cardiovascular & Coronary Research

Mazdutide is being investigated for its effects on cardiovascular health. Research applications include:

• Coronary Plaque Studies: A multicentre, randomised, double‑blind, placebo‑controlled trial is evaluating the effect of mazdutide on coronary plaque progression assessed by coronary computed tomography angiography (CCTA).

• Cardiovascular Risk Factors: Investigating improvements in blood pressure, lipid profiles, and inflammatory markers.

• Cardiovascular‑Metabolic Research: Exploring the broader therapeutic potential of dual agonism in addressing the interconnected pathways of cardiovascular and metabolic disease.

5. Uric Acid & Metabolic Research

Emerging research has explored mazdutide’s effects on uric acid metabolism. Research applications include:

• Hyperuricemia Models: Investigating the uric acid‑lowering effect of mazdutide in hyperuricemic rats through transcriptomics‑based exploration.

• Purine Metabolism: Studying how mazdutide influences purine metabolism and uric acid clearance.

Chemical & Physical Specifications

Accurate characterisation of Mazdutide research peptide is essential for reproducible experimental design.

Note: Mazdutide is supplied as a lyophilised powder for research use only (RUO). It is not FDA‑approved for human use and is supplied strictly for in‑vitro and in‑vivo scientific research.

Reconstitution & Handling Protocol for Mazdutide

Proper reconstitution of Mazdutide research peptide is critical for maintaining its structural integrity and biological activity.

Step 1 – Preparation

• Bring the sealed Mazdutide vial and your chosen diluent (sterile bacteriostatic water or sterile PBS, pH 5‑7) to room temperature. Condensation can degrade the lyophilised powder.

• Clean your work surface with 70% ethanol and lay out sterile syringes, alcohol wipes and a clean work mat.

Step 2 – Vial Sanitisation

• Wipe the rubber stopper of the Mazdutide vial with a fresh 70% ethanol wipe. Allow the alcohol to evaporate completely before piercing.

Step 3 – Reconstitution

• Draw your desired volume of diluent into a sterile syringe. A common starting concentration for research applications is 1‑2 mg per 1 mL of diluent, yielding a 1‑2 mg/mL stock solution.

• Insert the needle and slowly inject the diluent against the inner glass wall. Do not spray directly onto the lyophilised powder.

• Gently swirl the vial until the solution is clear and fully dissolved. Do not shake vigorously, as shaking can cause denaturation.

Step 4 – Aliquoting & Storage

• Immediately after dissolution, aliquot the reconstituted Mazdutide into single‑use sterile vials.

• Store aliquots at –20°C. Avoid repeated freeze‑thaw cycles, as peptides are susceptible to degradation.

• Once thawed, store at 2‑8°C and use within a short period.

Concentration Reference Table

Adjust diluent volume based on your experimental requirements. For cell culture applications, typical working concentrations may range from 0.1‑10 µM.

Storage & Stability Guidelines

Why Choose Chinese Grey Peptides for Mazdutide?

As an authentic licensed peptide supplier based in the USA, we supply Mazdutide research peptide and a wide range of research‑grade compounds under rigorous quality assurance protocols, fully aligned with Google’s E‑E‑A‑T standards (Experience, Expertise, Authoritativeness, Trustworthiness).

• Verified Purity: Independent HPLC analysis with purity guaranteed ≥99% for every batch.

• GMP‑Compliant Manufacturing: All peptides are synthesised under strict quality control conditions.

• Full Traceability: Batch‑specific Certificates of Analysis (COA) are available for every order.

• Wholesale Supply: We serve research institutions, laboratories, and wholesale buyers across the UK, EU, and USA with flexible volume pricing and reliable logistics.

• USA‑Based Regulatory Compliance: All products are supplied strictly as research‑grade reagents for laboratory use only (RUO).

Researchers across the United States—including those at leading institutions—trust us for fast domestic delivery, transparent documentation and professional technical support.

FAQ: Mazdutide Research Peptide

What is Mazdutide research peptide?
Mazdutide (IBI‑362, LY‑3305677) is a long‑acting synthetic analogue of oxyntomodulin that functions as a dual agonist of the glucagon‑like peptide‑1 receptor (GLP‑1R) and the glucagon receptor (GCGR). It is used in research to study obesity, type 2 diabetes, MASLD, and metabolic regulation.

What is the sequence and molecular weight of Mazdutide?
Mazdutide is a 34‑amino‑acid peptide with a molecular formula of C₂₁₀H₃₂₂N₄₆O₆₇ and a molecular weight of approximately 4563.06‑4563.07 g/mol.

 What is the mechanism of action of Mazdutide?
Mazdutide binds to GLP‑1R (Ki = 28.6 nM) and GCGR (Ki = 17.7 nM), stimulating glucose‑dependent insulin secretion, appetite suppression, and energy expenditure. It stimulates insulin secretion from mouse islets with an EC₅₀ of 5.2 nM.

What are the primary research applications for Mazdutide?
Mazdutide is used in obesity and weight regulation research, type 2 diabetes research, MASLD research, cardiovascular and coronary research, and uric acid and metabolic research.

What clinical trial data support Mazdutide’s efficacy?
In a Phase 3 head‑to‑head trial, 48.0% of participants in the mazdutide group achieved both HbA1c <7% and ≥10% weight loss, compared to 21.0% for semaglutide. A Phase 2 trial of 9 mg mazdutide in Chinese adults with obesity demonstrated substantial weight loss. Mazdutide has been approved at 4 and 6 mg for weight management in China.

What purity does your Mazdutide research peptide meet?
Our Mazdutide is tested to ≥99% purity by HPLC. A Certificate of Analysis (COA) is supplied with every order.

 How should I reconstitute Mazdutide research peptide?
Reconstitute with sterile bacteriostatic water or sterile PBS (pH 5‑7). Allow the vial to reach room temperature, then slowly inject the diluent against the inner glass wall and swirl gently. Do not shake.

How should I store reconstituted Mazdutide?
Reconstituted Mazdutide should be stored at 2‑8°C for short‑term use. For longer storage, aliquot immediately into single‑use vials and store at –20°C for up to 3 months. Avoid repeated freeze‑thaw cycles.

Is Mazdutide research peptide legal to purchase in the USA?
Yes. Mazdutide is a laboratory reagent sold for research use only (RUO). It is fully legal to purchase, possess, and use in the United States for legitimate in‑vitro or in‑vivo scientific research, provided it is not marketed with therapeutic claims.

Does Chinese Grey Peptides ship internationally?
Yes. We ship across the UK, Europe (France, Germany, Spain, Sweden, Italy), and the USA from our US warehouse. Wholesale pricing is available for bulk orders.

Ships to USA, Canada, UK & Europe

Chinese Grey Peptides supports shipping to the USA, Canada, the United Kingdom, France, Germany, Spain, Sweden, Italy, and Europe where permitted.

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Shipping times may vary by order size, carrier, destination, customs process, and local requirements.

Why Choose Chinese Grey Peptides?

Chinese Grey Peptides focuses on quality, support, and clear communication. We help buyers review product details before placing an order.

Customers choose us for:

• Professional peptide supplier support
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• PubChem Mazdutide — useful for compound identity and synonyms such as IBI362.
• PubMed Mazdutide literature — useful for research-context background on mazdutide as a dual GLP-1/glucagon receptor agonist.
• Innovent NMPA approval announcements — useful for jurisdiction-specific regulatory context in China.
• Google Search Central Product Structured Data — useful for product schema, ecommerce details, and search visibility.
• Rank Math WooCommerce Product Schema

From its design as a long‑acting oxyntomodulin analogue to its well‑characterised role as a balanced dual agonist of GLP‑1R and GCGR, Mazdutide research peptide provides a precisely defined and mechanistically advanced platform for metabolic research.

Its ability to simultaneously activate appetite‑suppressing and energy‑expending pathways—supported by receptor binding data (Ki = 17.7 nM for GCGR, 28.6 nM for GLP‑1R), functional activity (EC₅₀ = 5.2 nM for insulin secretion), and extensive clinical trial data published in JAMA, Diabetes, Obesity and Metabolism, and other authoritative journals—makes it a valuable addition to any laboratory investigating obesity, type 2 diabetes, MASLD, or the broader systemic effects of dual‑receptor signalling. By choosing high‑purity, lab‑verified Mazdutide research peptide from Chinese Grey Peptides, you ensure that your research is built on a foundation of quality, reproducibility, and scientific integrity.

Ready to advance your research with Mazdutide? Browse our product catalogue, request a wholesale quote, or contact our support team today to discuss your laboratory’s specific needs. Place your order now and receive GMP‑grade Mazdutide delivered directly to your facility in the USA, UK, or Europe.