Vesilut (20mg) Research Peptide: A Glu‑Asp Dipeptide Bioregulator for Urogenital & Epigenetic Studies

If your research investigates tissue‑specific bioregulation, epigenetic modulation, or the molecular mechanisms underlying urogenital function and cellular aging, Vesilut (20mg) research peptide — also known as Vesilute or ED (Glu‑Asp) — offers a precisely defined synthetic tool within the Khavinson family of peptide bioregulators. Vesilut is a dipeptide composed of glutamic acid and aspartic acid that is classified as a gene modulator hypothesised to interact directly with chromatin structures, potentially reactivating genes that become silenced with age.

Due to its similarity with the related Khavinson peptide Prostamax (Lys‑Glu‑Asp‑Pro), Vesilut is expected to exhibit comparable tissue‑specific activity on prostate and bladder cells. Clinical research has demonstrated that Vesilut treatment can increase bladder storage capacity from 267 mL to 320 mL and reduce daytime urination frequency from 14 to 11 episodes in women with overactive bladder syndrome. This makes Vesilut (20mg) research peptide a valuable tool for laboratories investigating urogenital function, epigenetics, chromatin dynamics, and the fundamental biology of cellular aging.

At Chinese Grey Peptides, we supply high‑purity Vesilut (20mg) research peptide to research institutions and wholesale buyers across the United Kingdom, France, Germany, Spain, Sweden, Italy, and the USA. Every batch is lyophilised, HPLC‑verified to ≥99% purity, and accompanied by a Certificate of Analysis (COA), ensuring your investigations into bioregulation, urogenital health, and genomic stability begin with uncompromising quality.

What Is Vesilut and How Does It Work?

To fully appreciate the research potential of Vesilut (20mg) research peptide, it is essential to understand its biochemical identity and the mechanisms by which it exerts its tissue‑specific effects.

The Glu‑Asp Dipeptide

Vesilut is a synthetic dipeptide consisting of two amino acids: glutamic acid (Glu) and aspartic acid (Asp), with the sequence H‑Glu‑Asp‑OH (ED). Its molecular formula is C₉H₁₄N₂O₇, and its molecular weight is approximately 262.20 g/mol. It has a CAS number of 3918‑84‑1 and a PubChem CID of 99716. The peptide is a member of the Khavinson family of short peptide bioregulators — molecules hypothesised to penetrate cell membranes and interact directly with chromatin to modulate gene expression.

Mechanism of Action: Chromatin Interaction and Gene Modulation

The biological activity of Vesilut (20mg) research peptide is hypothesised to involve several intersecting mechanisms that distinguish it from receptor‑mediated signalling peptides:

Chromatin Interaction and Epigenetic Modulation

Vesilut is posited to have a specific affinity for parts of the DNA, such as the ATTT sequence — one adenine and three thymine nucleotides. By interacting with chromatin structures in the cellular nucleus, Vesilut may induce chromatin decondensation, transforming tightly packed heterochromatin (associated with gene silencing) into more accessible euchromatin (associated with active gene expression). This modulation may reactivate genes that have been deactivated over time due to cellular aging.

Chromosomal Stability and Repair

Vesilut may influence chromosome dynamics by increasing the rate of sister chromatid exchanges (SCEs) — endogenous processes during cell division where identical sister chromatids exchange segments of genetic material. An increased frequency of these exchanges may indicate that Vesilut supports chromosomal repair and maintenance mechanisms, potentially aiding genomic stability in the process of cellular aging.

Ribosomal Gene Activation

Similar bioregulatory peptides may affect the activity of ribosomal RNA (rRNA) genes, as suggested by an observed increase in silver‑stained nucleolus organizer regions (Ag‑NORs). An elevated number of Ag‑NORs might imply better‑supported production of rRNA, leading to an increased capacity for protein synthesis — particularly significant in cells experiencing cellular aging, where the ability to synthesise proteins often declines.

Urogenital Tissue Modulation

Vesilut is hypothesised to modulate key signs of chronic inflammation at the cellular level, particularly within experimental models of chronic aseptic inflammation in prostate tissues. This includes reducing swelling in prostate tissues and attenuating hyperemia (excess blood in the vessels supplying the prostate gland). Additionally, related bioregulators appear to modulate cellular infiltration, a key indicator of immune response and inflammation.

Key Research Applications for Vesilut (20mg)

Vesilut (20mg) research peptide is a versatile tool with applications spanning several domains of biomedical research.

1. Urogenital & Bladder Function Research

Vesilut has been studied for its effects on bladder and prostate function. Research applications include:

• Bladder Smooth Muscle Function: Experimental animal studies have demonstrated Vesilute’s ability to normalise detrusor contractility parameters in rat models with infravesical obstruction.

• Overactive Bladder Syndrome: Prospective clinical research involving 20 women with overactive bladder syndrome showed statistically significant improvements following Vesilute treatment, including increased maximum cystometric capacity from 267 mL to 320 mL and a reduction in daytime urination frequency from 14 to 11 episodes daily.

• Prostate Health: Due to its similarity with Prostamax, Vesilut is expected to exhibit comparable action on prostate gland tissues, potentially modulating inflammation and reducing swelling.

2. Epigenetic & Chromatin Research

As a peptide that interacts with chromatin structures, Vesilut is a valuable tool for studying epigenetic regulation:

• Chromatin Dynamics: Investigating how short peptides can remodel higher‑order chromatin structures and influence gene accessibility.

• Heterochromatin Decondensation: Studying the unrolling of heterochromatin and its impact on gene expression.

• Gene Reactivation: Exploring the potential of Vesilut to restore the expression of genes silenced by age‑related chromatin condensation.

• Sister Chromatid Exchange: Investigating how Vesilut supports chromosomal repair and maintenance mechanisms.

3. Cellular Aging & Senescence Research

Vesilut has been hypothesised to play a role in modulating cellular aging processes:

• Age‑Related Chromatin Changes: Studying how Vesilut may reverse age‑associated chromatin condensation and restore gene expression.

• Protein Synthesis Support: Exploring how ribosomal gene activation may support protein synthesis in aged cells.

• Autophagy Modulation: Research suggests that Vesilut might influence autophagic processes by modulating signalling pathways involved in cellular recycling and degradation.

4. Inflammation & Immune Modulation Research

Vesilut has been studied for its potential to modulate inflammatory responses:

• Chronic Inflammation Models: Investigating how Vesilut modulates key signs of chronic inflammation at the cellular level in prostate and bladder tissues.

• Cellular Infiltration: Studying the potential role of Vesilut in modulating immune cell migration and activity, preventing excessive cellular infiltration.

• Sclerotic Process Prevention: Exploring how Vesilut may block the development of sclerotic processes, preventing the hardening of tissues that can result from prolonged inflammation.

5. Fundamental Genetic Research

Vesilut serves as a model system for studying how short peptides interact with DNA and chromatin:

• DNA‑Protein Interactions: Investigating how dipeptides bind to specific DNA sequences and modulate chromatin structure.

• Gene Regulation Studies: Exploring the potential of Vesilut as a tool for studying genetic regulation and chromatin remodeling.

Chemical & Physical Specifications for Vesilut (20mg)

Accurate characterisation of Vesilut (20mg) research peptide is essential for reproducible experimental design.

Note: The 20 mg mass refers to the weight of the peptide in its lyophilised form. Vesilut is a Khavinson peptide dipeptide bioregulator. The peptide is for research use only (RUO). Not for human use.

Reconstitution & Handling Protocol for Vesilut (20mg)

Proper reconstitution of Vesilut (20mg) research peptide is critical for maintaining its structural integrity and biological activity. The peptide is soluble in water and aqueous solutions.

Step 1 – Preparation

• Bring the sealed Vesilut vial and your chosen diluent (sterile bacteriostatic water or sterile PBS, pH 5‑7) to room temperature. Condensation can degrade the lyophilised powder.

• Clean your work surface with 70% ethanol and lay out sterile syringes, alcohol wipes and a clean work mat.

Step 2 – Vial Sanitisation

• Wipe the rubber stopper of the Vesilut vial with a fresh 70% ethanol wipe. Allow the alcohol to evaporate completely before piercing.

Step 3 – Reconstitution

• Draw your desired volume of diluent into a sterile syringe. A common starting concentration for research applications is 20 mg per 2 mL of diluent, yielding a 10 mg/mL stock solution.

• Insert the needle and slowly inject the diluent against the inner glass wall. Do not spray directly onto the lyophilised powder.

• Gently swirl the vial until the solution is clear and fully dissolved. Do not shake vigorously, as shaking can cause denaturation.

Step 4 – Aliquoting & Storage

• Immediately after dissolution, aliquot the reconstituted Vesilut into single‑use sterile vials.

• Store aliquots at –20°C. Avoid repeated freeze‑thaw cycles, as peptides are susceptible to degradation.

• Once thawed, store at 2‑8°C and use within a short period.

Concentration Reference Table for Vesilut (20mg)

Adjust diluent volume based on your experimental requirements. For cell culture applications, typical working concentrations may range from 0.1‑10 µM.

Storage & Stability Guidelines for Vesilut (20mg)

Why Choose Chinese Grey Peptides for Vesilut (20mg)?

As an authentic licensed peptide supplier based in the USA, we supply Vesilut (20mg) research peptide and a wide range of research‑grade compounds under rigorous quality assurance protocols, fully aligned with Google’s E‑E‑A‑T standards (Experience, Expertise, Authoritativeness, Trustworthiness).

• Verified Purity: Independent HPLC analysis with purity guaranteed ≥99% for every batch.

• GMP‑Compliant Manufacturing: All peptides are synthesised under strict quality control conditions.

• Full Traceability: Batch‑specific Certificates of Analysis (COA) are available for every order.

• Wholesale Supply: We serve research institutions, laboratories, and wholesale buyers across the UK, EU, and USA with flexible volume pricing and reliable logistics.

• USA‑Based Regulatory Compliance: All products are supplied strictly as research‑grade reagents for laboratory use only (RUO).

Researchers across the United States—including those at leading institutions—trust us for fast domestic delivery, transparent documentation and professional technical support.

FAQ: Vesilut (20mg) Research Peptide

 What is Vesilut (20mg) research peptide?
Vesilut (also known as Vesilute or ED) is a synthetic dipeptide composed of glutamic acid and aspartic acid (Glu‑Asp). It is a Khavinson peptide bioregulator used in research to study urogenital function, epigenetic modulation, and cellular aging.

 What is the sequence and molecular weight of Vesilut?
The sequence is H‑Glu‑Asp‑OH (ED). Its molecular formula is C₉H₁₄N₂O₇, and its molecular weight is approximately 262.20 g/mol.

 What are the primary research applications for Vesilut?
Vesilut is used in urogenital and bladder function research (bladder smooth muscle, overactive bladder syndrome, prostate health), epigenetic and chromatin research (chromatin dynamics, gene reactivation), cellular aging and senescence research, inflammation and immune modulation research, and fundamental genetic research.

What is the mechanism of action of Vesilut?
Vesilut is hypothesised to interact with chromatin structures in the cellular nucleus, inducing chromatin decondensation and reactivating genes that have been silenced over time. It may also influence chromosomal repair mechanisms, increase ribosomal RNA gene activity, and modulate inflammatory responses in urogenital tissues.

 What clinical data support Vesilut’s effects on bladder function?
Prospective research involving 20 women with overactive bladder syndrome showed statistically significant improvements following Vesilute treatment, including increased bladder storage capacity from 267 mL to 320 mL and a reduction in daytime urination frequency from 14 to 11 episodes daily.

 What purity does your Vesilut (20mg) meet?
Our Vesilut is tested to ≥99% purity by HPLC. A Certificate of Analysis (COA) is supplied with every order.

 How should I reconstitute Vesilut (20mg)?
Reconstitute with sterile bacteriostatic water or sterile PBS (pH 5‑7). Allow the vial to reach room temperature, then slowly inject the diluent against the inner glass wall and swirl gently. Do not shake. A typical starting concentration is 10 mg/mL.

 How should I store reconstituted Vesilut?
Reconstituted Vesilut should be stored at 2‑8°C for short‑term use. For longer storage, aliquot immediately into single‑use vials and store at –20°C for up to 3 months. Avoid repeated freeze‑thaw cycles.

 Is Vesilut research peptide legal to purchase in the USA?
Yes. Vesilut is a laboratory reagent sold for research use only (RUO). It is fully legal to purchase, possess, and use in the United States for legitimate in‑vitro or in‑vivo scientific research, provided it is not marketed with therapeutic claims.

Does Chinese Grey Peptides ship internationally?
Yes. We ship across the UK, Europe (France, Germany, Spain, Sweden, Italy), and the USA from our US warehouse. Wholesale pricing is available for bulk orders.

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Chinese Grey Peptides supports shipping to the USA, Canada, the United Kingdom, France, Germany, Spain, Sweden, Italy, and Europe where permitted.

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Why Choose Chinese Grey Peptides?

Chinese Grey Peptides focuses on quality, support, and clear communication. We help buyers review product details before placing an order.

Customers choose us for:

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• PubChem Na-L-Glutamyl-L-aspartic acid — useful for the ED / Glu-Asp peptide identity reference.
• ChEBI Glu-Asp — useful for defining Glu-Asp as a dipeptide.
• PubMed crystal structure paper for alpha-L-glutamyl-L-aspartic acid — useful as a scientific reference for Glu-Asp structure.
• Google Merchant Listing Structured Data — useful for product schema, ecommerce details, and search visibility. Google says Product markup can make pages eligible for merchant listing experiences in Google Search.
• Rank Math WooCommerce Product Schema

From its discovery as a Khavinson peptide bioregulator to its well‑characterised role in chromatin modulation, urogenital tissue regulation, and cellular aging research, Vesilut (20mg) research peptide provides a precisely defined and increasingly valuable platform for advanced epigenetic and urogenital research. Its ability to induce chromatin decondensation, reactivate age‑silenced genes, modulate inflammatory responses, and support bladder function—supported by clinical research demonstrating improved bladder storage capacity and reduced urination frequency—makes it a valuable addition to any laboratory investigating bioregulation, epigenetics, urogenital health, or the fundamental biology of cellular aging. By choosing high‑purity, lab‑verified Vesilut (20mg) research peptide from Chinese Grey Peptides, you ensure that your research is built on a foundation of quality, reproducibility, and scientific integrity.

Ready to advance your research with Vesilut (20mg)? Browse our product catalogue, request a wholesale quote, or contact our support team today to discuss your laboratory’s specific needs. Place your order now and receive GMP‑grade Vesilut delivered directly to your facility in the USA, UK, or Europe.