HMG 75 IU Research Peptide: A Glycoprotein Hormone for Fertility & Endocrine Studies

If your research investigates reproductive endocrinology, gonadotropin signalling, or the molecular mechanisms of fertility regulation, HMG 75 IU research peptide — also known as Human Menopausal Gonadotropin — offers a precisely defined and extensively validated synthetic tool. HMG is a glycoprotein hormone composed of a combination of luteinising hormone (LH) and follicle‑stimulating hormone (FSH) extracted from the urine of postmenopausal women.

Each 75 IU vial of HMG contains 75 IU of FSH bioactivity and 75 IU of LH bioactivity. It is primarily used for the treatment of infertility in women, particularly for inducing ovulation and controlled ovarian hyperstimulation in assisted reproductive technology. HMG is approved for clinical use and remains widely used in both clinical and research settings. This makes HMG 75 IU research peptide an invaluable tool for laboratories investigating reproductive biology, gonadotropin signalling, and endocrine regulation.

At Chinese Grey Peptides, we supply high‑purity HMG 75 IU research peptide to research institutions and wholesale buyers across the United Kingdom, France, Germany, Spain, Sweden, Italy, and the USA. Every batch is lyophilised, tested for biological activity, and accompanied by a Certificate of Analysis (COA), ensuring your investigations into reproductive endocrinology and gonadotropin signalling begin with uncompromising quality.

What Is HMG 75 IU and How Does It Work?

To fully appreciate the research potential of HMG 75 IU research peptide, it is essential to understand its biochemical structure, its mechanism of action, and its distinct pharmacological properties.

The Glycoprotein Hormone

HMG is a glycoprotein hormone composed of a combination of LH and FSH extracted from the urine of postmenopausal women. Each 75 IU vial of HMG contains 75 IU of FSH bioactivity and 75 IU of LH bioactivity. The reconstituted solution has a pH of 5.0‑7.0 and is supplied as a white to off‑white lyophilised cake.

Mechanism of Action: FSH and LH Receptor Agonism

The biological activity of HMG 75 IU research peptide is mediated through its action as a combination of FSH and LH receptor agonists:

• FSH Receptor Binding: FSH binds to FSH receptors on ovarian granulosa cells, stimulating follicular growth and maturation.

• LH Receptor Binding: LH binds to LH receptors on ovarian theca cells, stimulating androgen production and supporting follicular development.

• Synergistic Follicular Development: The combination of FSH and LH activity promotes the development of multiple follicles for assisted reproductive technologies.

• Ovulation Induction: HMG induces follicular maturation and is followed by treatment with chorionic gonadotrophin to stimulate ovulation and corpus luteum formation.

Pharmacokinetic Profile

HMG is administered via intramuscular or subcutaneous injection. The recommended initial dose is 75‑150 IU daily, which should be maintained for at least 7 days. Dose adjustments should not be made more frequently than every 7 days, with a recommended increment of 37.5 IU per adjustment.

Key Research Applications for HMG 75 IU

HMG 75 IU research peptide is a versatile tool with applications spanning several domains of biomedical research.

1. Reproductive Endocrinology & Fertility Research

As a combination of FSH and LH, HMG is an essential tool for studying reproductive biology. Research applications include:

• Ovulation Induction Studies: Investigating the mechanisms of ovulation induction and follicular development.

• Controlled Ovarian Hyperstimulation: Studying the development of multiple follicles for assisted reproductive technologies (ART) such as IVF/ET, GIFT, and ICSI.

• Anovulation Research: Exploring the treatment of anovulation, including polycystic ovarian disease (PCOD) in women who have been unresponsive to clomiphene citrate.

• Ovarian Response Studies: Investigating the inter‑individual variations in ovarian response to exogenous gonadotrophins.

2. Male Reproductive & Endocrine Research

HMG has been investigated for its effects on male infertility and hypogonadism:

• Hypogonadotrophic Hypogonadism: HMG may be given in combination with human chorionic gonadotrophin for the stimulation of spermatogenesis.

• Spermatogenesis Studies: Investigating the role of FSH and LH in sperm production and male fertility.

• Male Infertility Research: Exploring the treatment of male hypogonadism (delayed puberty, low sperm count) and male infertility.

3. Gonadotropin Receptor Signalling Research

As a well‑characterised combination of FSH and LH, HMG serves as a reference standard for studying receptor pharmacology:

• Receptor Binding Assays: Characterising the binding affinity and kinetics of FSH and LH receptor ligands.

• Signal Transduction Studies: Dissecting the signalling pathways activated by FSH and LH receptor engagement.

• Comparative Studies: Comparing the effects of HMG with recombinant FSH and LH preparations.

4. IVF & Assisted Reproductive Technology Research

HMG is widely used in IVF and ART research:

• Personalised Dosing Algorithms: Investigating the use of personalised dosing regimens for ovarian stimulation.

• Mixed Gonadotrophin Regimens: Studying the efficacy of mixed protocols using HMG with recombinant FSH preparations.

• Clinical Pregnancy Outcomes: Assessing the clinical pregnancy rate (CPR) per embryo transfer cycle.

5. Low‑Dose Stimulation Research

HMG at 75 IU/day is used in studies investigating low‑dose ovarian stimulation:

• Ovarian Hyperstimulation Syndrome Prevention: Assessing the value of using a low dose of hMG (75 IU/day) to achieve ovarian stimulation in women at risk of ovarian hyperstimulation syndrome.

• Exaggerated Response Models: Investigating the use of low‑dose HMG in women who have previously shown an exaggerated response to a standard dose.

Chemical & Physical Specifications

Accurate characterisation of HMG 75 IU research peptide is essential for reproducible experimental design.

Note: HMG is a glycoprotein hormone combination of FSH and LH. It is supplied as a lyophilised powder for research use only (RUO).

Reconstitution & Handling Protocol for HMG 75 IU

Proper reconstitution of HMG 75 IU research peptide is critical for maintaining its structural integrity and biological activity.

Step 1 – Preparation

• Bring the sealed HMG vial and your chosen diluent (sterile bacteriostatic water or sterile PBS, pH 5‑7) to room temperature.

• Clean your work surface with 70% ethanol and lay out sterile syringes, alcohol wipes and a clean work mat.

Step 2 – Vial Sanitisation

• Wipe the rubber stopper of the HMG vial with a fresh 70% ethanol wipe. Allow the alcohol to evaporate completely before piercing.

Step 3 – Reconstitution

• Draw your desired volume of diluent into a sterile syringe. A common starting concentration is 1 mL per 75 IU vial.

• Insert the needle and slowly inject the diluent against the inner glass wall. Do not spray directly onto the lyophilised powder.

• Gently swirl the vial until the solution is clear and fully dissolved. Do not shake vigorously, as shaking can cause denaturation.

Step 4 – Storage and In‑Use Management

• Once reconstituted, the solution must be refrigerated (2‑8°C).

• Reconstituted HMG is stable when refrigerated for up to 28 days.

• Record the date of reconstitution on the vial label.

Concentration Reference Table

Adjust diluent volume based on your experimental requirements.

Storage & Stability Guidelines

Why Choose Chinese Grey Peptides for HMG 75 IU?

As an authentic licensed peptide supplier based in the USA, we supply HMG 75 IU research peptide and a wide range of research‑grade compounds under rigorous quality assurance protocols, fully aligned with Google’s E‑E‑A‑T standards (Experience, Expertise, Authoritativeness, Trustworthiness).

• Verified Biological Activity: Each batch is tested for FSH and LH bioactivity.

• GMP‑Compliant Manufacturing: All products are manufactured under strict quality control conditions.

• Full Traceability: Batch‑specific Certificates of Analysis (COA) are available for every order.

• Wholesale Supply: We serve research institutions, laboratories, and wholesale buyers across the UK, EU, and USA with flexible volume pricing and reliable logistics.

• USA‑Based Regulatory Compliance: All products are supplied strictly as research‑grade reagents for laboratory use only (RUO).

Researchers across the United States—including those at leading institutions—trust us for fast domestic delivery, transparent documentation and professional technical support.

FAQ: HMG 75 IU Research Peptide

 What is HMG 75 IU research peptide?
HMG (Human Menopausal Gonadotropin) is a glycoprotein hormone composed of a combination of luteinising hormone (LH) and follicle‑stimulating hormone (FSH) extracted from the urine of postmenopausal women. Each 75 IU vial contains 75 IU of FSH bioactivity and 75 IU of LH bioactivity.

What is the mechanism of action of HMG?
HMG acts as a combination of FSH and LH receptor agonists, stimulating follicular growth, maturation, and ovulation in females, and spermatogenesis in males.

 What are the primary research applications for HMG?
HMG is used in reproductive endocrinology and fertility research (ovulation induction, controlled ovarian hyperstimulation), male reproductive and endocrine research (hypogonadotrophic hypogonadism, spermatogenesis), gonadotropin receptor signalling studies, IVF and ART research, and low‑dose stimulation research.

 How is HMG administered in research?
HMG is administered via intramuscular or subcutaneous injection.

 What is the recommended initial dose of HMG?
The recommended initial dose is 75‑150 IU daily, which should be maintained for at least 7 days.

 How should I reconstitute HMG 75 IU?
Reconstitute with sterile bacteriostatic water or sterile PBS (pH 5‑7). Allow the vial to reach room temperature, then slowly inject the diluent against the inner glass wall and swirl gently. Do not shake. A typical starting concentration is 1 mL per 75 IU vial.

 How should I store reconstituted HMG?
Once reconstituted, the solution must be refrigerated (2‑8°C). Reconstituted HMG is stable when refrigerated for up to 28 days.

Is HMG research peptide legal to purchase in the USA?
Yes. HMG is a laboratory reagent sold for research use only (RUO). It is fully legal to purchase, possess, and use in the United States for legitimate in‑vitro or in‑vivo scientific research, provided it is not marketed with therapeutic claims.

Does Chinese Grey Peptides ship internationally?
Yes. We ship across the UK, Europe (France, Germany, Spain, Sweden, Italy), and the USA from our US warehouse. Wholesale pricing is available for bulk orders.

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• DailyMed Menopur / menotropins label
• UK electronic Medicines Compendium Menopur 75 IU SmPC
• Google Search Central Product Structured Data
• FDA peptide warning letter

From its role as a glycoprotein hormone combination of FSH and LH to its well‑characterised functions in ovulation induction, follicular development, and spermatogenesis, HMG 75 IU research peptide provides a precisely defined and extensively validated platform for advanced reproductive and endocrine research. Its ability to stimulate follicular growth and maturation, induce ovulation, and support spermatogenesis—supported by peer‑reviewed research published in PubMed, ScienceDirect, and other authoritative sources—makes it a valuable addition to any laboratory investigating reproductive endocrinology, gonadotropin signalling, or fertility regulation. By choosing high‑purity, biologically active HMG 75 IU research peptide from Chinese Grey Peptides, you ensure that your research is built on a foundation of quality, reproducibility, and scientific integrity.

Ready to advance your research with HMG 75 IU? Browse our product catalogue, request a wholesale quote, or contact our support team today to discuss your laboratory’s specific needs. Place your order now and receive GMP‑grade HMG delivered directly to your facility in the USA, UK, or Europe.