Vilon (20mg) Research Peptide: A Lys‑Glu Dipeptide Bioregulator for Immunomodulation, Chromatin & Aging Studies

If your research investigates immune senescence, chromatin dynamics, or the molecular mechanisms underpinning cellular aging, Vilon (20mg) research peptide — also known as the KE dipeptide (Lys‑Glu) — offers a precisely defined and mechanistically distinct synthetic tool. Vilon is one of the shortest known biologically active peptides, consisting of just two amino acids: lysine and glutamic acid. Developed within the Khavinson family of peptide bioregulators, this minimalist structure is theorised to penetrate cells and interact directly with nuclear chromatin, promoting the unwrapping of facultative heterochromatin without disturbing structural integrity.

As a thymomimetic, Vilon has been shown to stimulate the differentiation of immune cell precursors, modulate gene expression, and influence telomere dynamics. This makes Vilon (20mg) research peptide a valuable tool for laboratories investigating immunomodulation, epigenetic regulation, and the fundamental biology of aging.

At Chinese Grey Peptides, we supply high‑purity Vilon (20mg) research peptide to research institutions and wholesale buyers across the United Kingdom, France, Germany, Spain, Sweden, Italy, and the USA. Every batch is lyophilised, HPLC‑verified to ≥99% purity, and accompanied by a Certificate of Analysis (COA), ensuring your investigations into immune regulation, chromatin biology, and geroprotection begin with uncompromising quality.

What Is Vilon and How Does It Work?

To fully appreciate the research potential of Vilon (20mg) research peptide, it is essential to understand its biochemical identity and the mechanisms by which it exerts its pleiotropic effects.

The KE Dipeptide

Vilon is a synthetic dipeptide composed of two amino acids: lysine and glutamic acid — the sequence Lys‑Glu (KE). As a member of the Khavinson family of peptide bioregulators, it is among the shortest peptides reported to exert significant biological activity. Its molecular formula is C₁₁H₂₁N₃O₅, with a molecular weight of approximately 275.30 g/mol. The peptide’s short length is theorised to allow for efficient cellular penetration and interaction with nuclear components, particularly chromatin. It is also referred to as a “cytogen” — a peptide that regulates gene expression at the chromatin level.

Mechanism of Action: Chromatin Remodelling, Immune Modulation & Geroprotection

The biological activity of Vilon (20mg) research peptide is mediated through several intersecting mechanisms, reflecting its classification as a gene‑modulating bioregulator:

Chromatin Decondensation and Epigenetic Regulation

Vilon’s hypothesised primary mechanism involves direct interaction with chromatin structure in the cell nucleus. Research indicates that Vilon promotes the unrolling deheterochromatinisation (decondensation) of total heterochromatin and deheterochromatinisation of satellite stalks of acrocentric chromosomes, activating synthetic processes of ribosomal genes. This process makes previously condensed, transcriptionally silent regions of DNA more accessible, potentially reactivating genes that become silenced with age. Notably, this effect is selective: it does not cause deheterochromatinisation of pericentromeric structural heterochromatin.

Telomere Dynamics and Cellular Senescence

Vilon has been shown to normalise telomere length in stimulated lymphocyte cultures across different age groups in laboratory conditions. This is a significant finding, as telomere shortening is a hallmark of cellular aging. Vilon increases the proportion of euchromatin (active, open chromatin) while decreasing heterochromatin (inactive, condensed chromatin) in aging cell models.

Immunomodulation and Thymic Support

As a thymomimetic peptide, Vilon stimulates the differentiation of immune cell precursors. It has been shown to induce the differentiation of precursors into T‑helper cells, cytotoxic T lymphocytes, and B cells. This action may play an important compensatory role in age‑related atrophy of the thymus, the central organ of the immune system. Vilon has demonstrated the most potent comitogenic effect on thymocyte proliferation among the Khavinson peptides, modulating the comitogenic activity of interleukin‑1β. It also modulates the activity of sphingomyelinase, a key enzyme in the sphingomyelin signalling pathway.

Gene Expression and Protein Synthesis

Vilon has been shown to regulate the expression of key genes involved in aging and cellular stress responses. It modulates the gene expression and protein synthesis of SIRT1, PARP1, and PARP2 during aging of human mesenchymal stem cells. SIRT1 is a well‑known longevity‑associated deacetylase, while PARP1 and PARP2 are involved in DNA repair and cellular stress responses.

Geroprotective and Anti‑Apoptotic Effects

Vilon has demonstrated significant geroprotective effects in research models. It produces positive effects on digestive enzyme activity during aging, diminishing age‑related differences. Additionally, Vilon inhibits irradiation‑induced apoptotic death of spleen lymphocytes in rats, with the antiapoptotic effect being more pronounced than that of epithalon.

Key Research Applications for Vilon (20mg)

Vilon (20mg) research peptide is a versatile tool with applications spanning several domains of biomedical research.

1. Immunology & Thymic Research

As a peptide that stimulates the differentiation of immune cell precursors and supports thymic function, Vilon is a valuable tool for studying immune senescence and restoration. Research applications include:

• T‑Cell Differentiation: Investigating how Vilon drives the differentiation of precursors into T‑helper cells, cytotoxic T lymphocytes, and B cells.

• Thymic Atrophy Models: Studying the potential compensatory role of Vilon in age‑related thymic involution.

• Immunocompromised Models: Exploring Vilon’s potential to support immune function in research models of immunodeficiency.

• Autoimmune Modulation: Investigating how Vilon may modulate autoimmune action by interacting with the thymus gland.

2. Chromatin & Epigenetic Research

Vilon’s ability to induce chromatin decondensation positions it as a valuable tool for studying epigenetic regulation and gene reactivation. Research applications include:

• Heterochromatin Decondensation: Investigating the selective unrolling of heterochromatin and its impact on gene expression.

• Ribosomal Gene Activation: Studying how Vilon activates synthetic processes of ribosomal genes.

• Epigenetic Rejuvenation: Exploring the potential of Vilon to restore the expression of genes silenced by age‑related chromatin condensation.

• Gene Regulation Studies: Investigating how Vilon modulates the expression of SIRT1, PARP1, and PARP2.

3. Aging & Gerontology Research

Vilon has demonstrated significant geroprotective effects across multiple research models. Research applications include:

• Telomere Dynamics: Investigating how Vilon normalises telomere length in aging cell cultures.

• Cellular Senescence: Studying how Vilon modulates the balance of euchromatin and heterochromatin in aging models.

• Digestive Enzyme Activity: Exploring how Vilon produces positive effects on digestive enzyme activity during aging.

• Anti‑Apoptotic Studies: Investigating how Vilon inhibits programmed cell death in various cell types.

4. Oxidative Stress & Mitochondrial Research

Vilon has been shown to modulate reactive oxygen species (ROS) generation in a compartment‑specific manner. Research applications include:

• Mitochondrial ROS: Investigating how Vilon inhibits ROS generation in mitochondria.

• Cytosolic ROS: Studying how Vilon stimulates ROS generation in the cytosol.

• Antioxidant Activity: Exploring sex‑ and age‑related differences in ROS generation and cytosol antioxidant activity.

5. Regenerative & Tissue Repair Research

Vilon has been investigated for its potential to promote tissue regeneration and cellular repair. Research applications include:

• Tissue Regeneration: Studying Vilon’s potential to promote recovery from injury and support the health of damaged tissues.

• Fibroblast Research: Investigating the effect of Vilon on the expression of aging markers in human fibroblasts.

• Organotypic Cultures: Exploring the tissue‑specific effects of Vilon on explants from various organs.

Chemical & Physical Specifications for Vilon (20mg)

Accurate characterisation of Vilon (20mg) research peptide is essential for reproducible experimental design.

Note: The 20 mg mass refers to the weight of the peptide in its lyophilised form. Vilon is a Khavinson peptide dipeptide bioregulator. The peptide is for research use only (RUO). Not for human use.

Reconstitution & Handling Protocol for Vilon (20mg)

Proper reconstitution of Vilon (20mg) research peptide is critical for maintaining its structural integrity and biological activity.

Step 1 – Preparation

• Bring the sealed Vilon vial and your chosen diluent (sterile bacteriostatic water or sterile PBS, pH 5‑7) to room temperature. Condensation can degrade the lyophilised powder.

• Clean your work surface with 70% ethanol and lay out sterile syringes, alcohol wipes and a clean work mat.

Step 2 – Vial Sanitisation

• Wipe the rubber stopper of the Vilon vial with a fresh 70% ethanol wipe. Allow the alcohol to evaporate completely before piercing.

Step 3 – Reconstitution

• Draw your desired volume of diluent into a sterile syringe. A common starting concentration for research applications is 20 mg per 2 mL of diluent, yielding a 10 mg/mL stock solution.

• Insert the needle and slowly inject the diluent against the inner glass wall. Do not spray directly onto the lyophilised powder.

• Gently swirl the vial until the solution is clear and fully dissolved. Do not shake vigorously, as shaking can cause denaturation.

Step 4 – Aliquoting & Storage

• Immediately after dissolution, aliquot the reconstituted Vilon into single‑use sterile vials.

• Store aliquots at –20°C. Avoid repeated freeze‑thaw cycles, as peptides are susceptible to degradation.

• Once thawed, store at 2‑8°C and use within a short period.

Concentration Reference Table for Vilon (20mg)

Adjust diluent volume based on your experimental requirements. For cell culture applications, typical working concentrations may range from 0.1‑10 µM.

Storage & Stability Guidelines for Vilon (20mg)

Why Choose Chinese Grey Peptides for Vilon (20mg)?

As an authentic licensed peptide supplier based in the USA, we supply Vilon (20mg) research peptide and a wide range of research‑grade compounds under rigorous quality assurance protocols, fully aligned with Google’s E‑E‑A‑T standards (Experience, Expertise, Authoritativeness, Trustworthiness).

• Verified Purity: Independent HPLC analysis with purity guaranteed ≥99% for every batch.

• GMP‑Compliant Manufacturing: All peptides are synthesised under strict quality control conditions.

• Full Traceability: Batch‑specific Certificates of Analysis (COA) are available for every order.

• Wholesale Supply: We serve research institutions, laboratories, and wholesale buyers across the UK, EU, and USA with flexible volume pricing and reliable logistics.

• USA‑Based Regulatory Compliance: All products are supplied strictly as research‑grade chemicals for laboratory use only (RUO).

Researchers across the United States—including those at leading institutions—trust us for fast domestic delivery, transparent documentation and professional technical support.

FAQ: Vilon (20mg) Research Peptide

 What is Vilon (20mg) research peptide?
Vilon is a synthetic dipeptide (Lys‑Glu, KE) belonging to the Khavinson family of peptide bioregulators. It is used in research to study immunomodulation, chromatin dynamics, and the molecular mechanisms of aging.

What is the sequence and molecular weight of Vilon?
The sequence is Lys‑Glu (KE). Its molecular formula is C₁₁H₂₁N₃O₅, and its molecular weight is approximately 275.30 g/mol.

What are the primary research applications for Vilon?
Vilon is used in immunology and thymic research (T‑cell differentiation, thymic atrophy models), chromatin and epigenetic research (heterochromatin decondensation, gene regulation), aging and gerontology research (telomere dynamics, cellular senescence), oxidative stress and mitochondrial research, and regenerative and tissue repair research.

 What is the mechanism of action of Vilon?
Vilon is hypothesised to interact directly with chromatin, inducing deheterochromatinisation and activating ribosomal genes. It also modulates telomere length, stimulates immune cell differentiation, and regulates the expression of aging‑related genes such as SIRT1, PARP1, and PARP2.

 How does Vilon affect the immune system?
Vilon is a thymomimetic peptide that stimulates the differentiation of precursors into T‑helper cells, cytotoxic T lymphocytes, and B cells. It has demonstrated the most potent comitogenic effect on thymocyte proliferation among the Khavinson peptides.

 What purity does your Vilon (20mg) meet?
Our Vilon is tested to ≥99% purity by HPLC. A Certificate of Analysis (COA) is supplied with every order.

 How should I reconstitute Vilon (20mg)?
Reconstitute with sterile bacteriostatic water or sterile PBS (pH 5‑7). Allow the vial to reach room temperature, then slowly inject the diluent against the inner glass wall and swirl gently. Do not shake. A typical starting concentration is 10 mg/mL.

 How should I store reconstituted Vilon?
Reconstituted Vilon should be stored at 2‑8°C for short‑term use. For longer storage, aliquot immediately into single‑use vials and store at –20°C for up to 3 months. Avoid repeated freeze‑thaw cycles.

Is Vilon research peptide legal to purchase in the USA?
Yes. Vilon is a laboratory reagent sold for research use only (RUO). It is fully legal to purchase, possess, and use in the United States for legitimate in‑vitro or in‑vivo scientific research, provided it is not marketed with therapeutic claims.

 Does Chinese Grey Peptides ship internationally?
Yes. We ship across the UK, Europe (France, Germany, Spain, Sweden, Italy), and the USA from our US warehouse. Wholesale pricing is available for bulk orders.

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• PubChem Lysylglutamic acid — useful for Vilon, Lys-Glu, KE, and compound identity reference.
• PubMed Vilon / Lys-Glu research reference — useful for research-context background without making medical or consumer-use claims.
• FDA peptide warning letter — useful for compliance awareness around “research use only” wording and avoided human-use claims.
• Google Merchant Center structured data guidance — useful because structured data can share product data with Google Merchant Center in a machine-readable format.
• Rank Math WooCommerce Product Schema

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From its discovery as a thymomimetic dipeptide to its well‑characterised role in chromatin decondensation, immunomodulation, and geroprotection, Vilon (20mg) research peptide provides a precisely defined and mechanistically distinct platform for advanced biological research. Its ability to induce deheterochromatinisation, normalise telomere length, stimulate immune cell differentiation, and regulate the expression of longevity‑associated genes—supported by decades of peer‑reviewed research published in PubMed and other authoritative journals—makes it a valuable addition to any laboratory investigating immune senescence, epigenetic regulation, or the fundamental biology of aging. By choosing high‑purity, lab‑verified Vilon (20mg) research peptide from Chinese Grey Peptides, you ensure that your research is built on a foundation of quality, reproducibility, and scientific integrity.

Ready to advance your research with Vilon (20mg)? Browse our product catalogue, request a wholesale quote, or contact our support team today to discuss your laboratory’s specific needs. Place your order now and receive GMP‑grade Vilon delivered directly to your facility in the USA, UK, or Europe.